PMID- 23429848 OWN - NLM STAT- MEDLINE DCOM- 20130517 LR - 20191027 IS - 1809-452X (Electronic) IS - 1516-4446 (Linking) VI - 34 Suppl 2 DP - 2012 Oct TI - BDNF gene polymorphism, cognition and symptom severity in a Brazilian population-based sample of first-episode psychosis subjects. PG - S219-25 LID - S1516-44462012000600007 [pii] AB - OBJECTIVE: To investigate the influence of brain-derived neurotrophic factor (BDNF) gene variations on cognitive performance and clinical symptomatology in first-episode psychosis (FEP). METHODS: We performed BDNF val66met variant genotyping, cognitive testing (verbal fluency and digit spans) and assessments of symptom severity (as assessed with the PANSS) in a population-based sample of FEP patients (77 with schizophreniform psychosis and 53 with affective psychoses) and 191 neighboring healthy controls. RESULTS: There was no difference in the proportion of Met allele carriers between FEP patients and controls, and no significant influence of BDNF genotype on cognitive test scores in either of the psychosis groups. A decreased severity of negative symptoms was found in FEP subjects that carried a Met allele, and this finding reached significance for the subgroup with affective psychoses (p < 0.01, ANOVA). CONCLUSIONS: These results suggest that, in FEP, the BDNF gene Val66Met polymorphism does not exert a pervasive influence on cognitive functioning but may modulate the severity of negative symptoms. FAU - Martinho, Eduardo Jr AU - Martinho E Jr AD - Department of Psychiatry, Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Michelon, Leandro AU - Michelon L FAU - Ayres, Adriana M AU - Ayres AM FAU - Scazufca, Marcia AU - Scazufca M FAU - Menezes, Paulo R AU - Menezes PR FAU - Schaufelberger, Maristela S AU - Schaufelberger MS FAU - Murray, Robin M AU - Murray RM FAU - Rushe, Teresa M AU - Rushe TM FAU - Vallada, Homero AU - Vallada H FAU - Busatto Filho, Geraldo AU - Busatto Filho G LA - eng LA - por GR - Wellcome Trust/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Brazil TA - Braz J Psychiatry JT - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) JID - 100895975 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adolescent MH - Adult MH - Brain-Derived Neurotrophic Factor/*genetics MH - Brazil MH - Cognition/*physiology MH - Female MH - Genotype MH - Humans MH - Male MH - Middle Aged MH - Polymorphism, Single Nucleotide/*genetics MH - Psychotic Disorders/*genetics MH - Severity of Illness Index MH - Young Adult EDAT- 2013/03/06 06:00 MHDA- 2013/05/18 06:00 CRDT- 2013/02/23 06:00 PHST- 2011/10/07 00:00 [received] PHST- 2012/02/29 00:00 [accepted] PHST- 2013/02/23 06:00 [entrez] PHST- 2013/03/06 06:00 [pubmed] PHST- 2013/05/18 06:00 [medline] AID - S1516-44462012000600007 [pii] AID - 10.1016/j.rbp.2012.06.004 [doi] PST - ppublish SO - Braz J Psychiatry. 2012 Oct;34 Suppl 2:S219-25. doi: 10.1016/j.rbp.2012.06.004.