PMID- 23430021
OWN - NLM
STAT- MEDLINE
DCOM- 20140109
LR  - 20220321
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 144
IP  - 2
DP  - 2013 Aug
TI  - Patient-reported outcomes assessed by the CAMPHOR questionnaire predict clinical 
      deterioration in idiopathic pulmonary arterial hypertension and chronic 
      thromboembolic pulmonary hypertension.
PG  - 522-530
LID - S0012-3692(13)60528-0 [pii]
LID - 10.1378/chest.12-2443 [doi]
AB  - BACKGROUND: The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) is a 
      disease-specific assessment tool used for the evaluation and follow-up of 
      patients with pulmonary hypertension (PH). We describe a novel use for this 
      questionnaire in its potential to predict clinical deterioration (CD) in two 
      patient cohorts with subtypes of PH, idiopathic pulmonary arterial hypertension 
      (IPAH), and chronic thromboembolic pulmonary hypertension (CTEPH) during an 
      8-year period. METHODS: We retrospectively analyzed CAMPHOR scores obtained at 
      baseline and at follow-up visits in patients under the care of our unit over an 
      8-year period to assess CD and survival, as well as 6-min walk distance (6MWD) 
      and New York Heart Association (NYHA) class. RESULTS: Using Cox regression, we 
      demonstrated a significant predictive effect of CD from total CAMPHOR scores at 
      study enrollment in IPAH and CTEPH (hazard ratios, 1.03 [95% CI, 1.01-1.05] and 
      1.04 [95% CI, 1.02-1.06] per unit score increase, respectively), as well as from 
      CAMPHOR subscales as independent predictors. This predictive effect is diluted 
      after adjusting for the prognostic effect of 6MWD and NYHA class. Repeated 
      CAMPHOR assessment over time appears not to add predictive value of CD to that 
      obtained at diagnosis, although it still informs physicians of important changes 
      in self-reported symptoms. CONCLUSIONS: When emphasis is placed on the evaluation 
      of patient perceptions, CAMPHOR may represent an alternative method of estimating 
      the likelihood of CD.
FAU - McCabe, Colm
AU  - McCabe C
AD  - Pulmonary Vascular Disease Unit, Papworth Hospital NHS Trust, Cambridge, England.
FAU - Bennett, Maxine
AU  - Bennett M
AD  - MRC Biostatistics Unit, Institute of Public Health, Cambridge, England.
FAU - Doughty, Natalie
AU  - Doughty N
AD  - Pulmonary Vascular Disease Unit, Papworth Hospital NHS Trust, Cambridge, England.
FAU - MacKenzie Ross, Robert
AU  - MacKenzie Ross R
AD  - Pulmonary Vascular Disease Unit, Papworth Hospital NHS Trust, Cambridge, England.
FAU - Sharples, Linda
AU  - Sharples L
AD  - MRC Biostatistics Unit, Institute of Public Health, Cambridge, England.
FAU - Pepke-Zaba, Joanna
AU  - Pepke-Zaba J
AD  - Pulmonary Vascular Disease Unit, Papworth Hospital NHS Trust, Cambridge, England. 
      Electronic address: joanna.pepkezaba@papworth.nhs.uk.
LA  - eng
GR  - MC_U105232027/MRC_/Medical Research Council/United Kingdom
GR  - MC_UP_1302/2/MRC_/Medical Research Council/United Kingdom
GR  - 5UL1 RR025777/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - Chronic Disease
MH  - Disease Progression
MH  - Familial Primary Pulmonary Hypertension
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*etiology/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - *Surveys and Questionnaires
MH  - Thromboembolism/*complications
MH  - Walking/physiology
PMC - PMC4694098
EDAT- 2013/02/23 06:00
MHDA- 2014/01/10 06:00
PMCR- 2014/08/01
CRDT- 2013/02/23 06:00
PHST- 2013/02/23 06:00 [entrez]
PHST- 2013/02/23 06:00 [pubmed]
PHST- 2014/01/10 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - S0012-3692(13)60528-0 [pii]
AID - chest.12-2443 [pii]
AID - 10.1378/chest.12-2443 [doi]
PST - ppublish
SO  - Chest. 2013 Aug;144(2):522-530. doi: 10.1378/chest.12-2443.