PMID- 23430091
OWN - NLM
STAT- MEDLINE
DCOM- 20140626
LR  - 20211021
IS  - 1615-6692 (Electronic)
IS  - 0340-9937 (Linking)
VI  - 38
IP  - 7
DP  - 2013 Nov
TI  - Hyperhomocysteinemia is an independent risk factor in young patients with 
      coronary artery disease in southern China.
PG  - 779-84
LID - 10.1007/s00059-013-3761-y [doi]
AB  - BACKGROUND: Elevated plasma homocysteine (Hcy) is considered to be a risk factor 
      of coronary artery disease (CAD), although this is still controversially 
      discussed. This study investigated the role of Hcy in young patients with CAD in 
      southern China. METHODS: A total of 146 consecutive patients (aged </= 55 years) 
      with angiographically proven CAD were enrolled in the study and 138 age-matched 
      non-CAD individuals were included as the control group. Hcy levels were measured 
      by enzymatic assay. Hyperhomocysteinemia (HHcy) was defined as Hcy >/= 15 micromol/l. A 
      10-year CAD risk was calculated using the Framingham risk score (FRS) modified 
      according to the National Cholesterol Education Program Adult Treatment Panel 
      III. RESULTS: There were significant differences between the CAD and control 
      groups with regard to male sex (P < 0.01), smoking history (P < 0.05), and 
      triglyceride levels (TG, P < 0.05), but no remarkable difference in other 
      conventional risk factors (all P > 0.05). Hcy and high-sensitivity C-reactive 
      protein (hs-CRP) levels were significantly higher in the CAD group than those in 
      the control group (both P < 0.05). The FRS and estimated 10-year absolute CAD 
      event risk were low in both groups and did not show a statistical difference. 
      Multivariate logistic regression showed that male sex (odds ratio, OR, 3.68; 95 % 
      confidence interval, 95 % CI, 1.54-10.01), smoking (OR, 2.54; 95 % CI, 
      1.15-5.36), TG (OR, 1.30; 95  % CI, 1.08-3.06), hs-CRP (OR, 3.74; 95 % CI, 
      1.72-12.21), and HHcy (OR, 2.03; 95 % CI, 1.26-5.83) were independently 
      correlated with CAD in young patients. CONCLUSION: HHcy is an important 
      independent risk factor for CAD in young patients in southern China after 
      adjusting for other risk factors.
FAU - Wu, Y
AU  - Wu Y
AD  - Department of Cardiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, PR China.
FAU - Huang, Y
AU  - Huang Y
FAU - Hu, Y
AU  - Hu Y
FAU - Zhong, J
AU  - Zhong J
FAU - He, Z
AU  - He Z
FAU - Li, W
AU  - Li W
FAU - Yang, Y
AU  - Yang Y
FAU - Xu, D
AU  - Xu D
FAU - Wu, S
AU  - Wu S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130222
PL  - Germany
TA  - Herz
JT  - Herz
JID - 7801231
RN  - 0 (Biomarkers)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Biomarkers/blood
MH  - China/epidemiology
MH  - Comorbidity
MH  - Coronary Artery Disease/*blood/diagnosis/*epidemiology
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*blood/diagnosis/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Sensitivity and Specificity
EDAT- 2013/02/23 06:00
MHDA- 2014/06/27 06:00
CRDT- 2013/02/23 06:00
PHST- 2012/12/12 00:00 [received]
PHST- 2013/01/11 00:00 [accepted]
PHST- 2013/01/06 00:00 [revised]
PHST- 2013/02/23 06:00 [entrez]
PHST- 2013/02/23 06:00 [pubmed]
PHST- 2014/06/27 06:00 [medline]
AID - 10.1007/s00059-013-3761-y [doi]
PST - ppublish
SO  - Herz. 2013 Nov;38(7):779-84. doi: 10.1007/s00059-013-3761-y. Epub 2013 Feb 22.