PMID- 23430242
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130225
LR  - 20220311
IS  - 1738-1088 (Print)
IS  - 2093-4327 (Electronic)
IS  - 1738-1088 (Linking)
VI  - 9
IP  - 3
DP  - 2011 Dec
TI  - Lack of Association between Brain-Derived Neurotrophic Factor Gene Val66Met 
      Polymorphisms and Generalized Social Anxiety Disorder in Korean Population.
PG  - 129-33
LID - 10.9758/cpn.2011.9.3.129 [doi]
AB  - OBJECTIVE: Several lines of evidence suggest that brain-derived neurotrophic 
      factor (BDNF) plays a role in the pathophysiology of anxiety. We analyzed the 
      association of the BDNF gene polymorphism, G196A (val66met), in the coding region 
      of exon XIIIA in chromosome 11p13, and generalized social anxiety disorder 
      (GSAD). METHODS: Patients with GSAD (n=73) and age-matched control subjects 
      (n=152) were tested for the BDNF (val66met) polymorphism. A clinical interview 
      and a Mini-International Neuropsychiatric Interview were conducted by trained 
      psychiatrists in order to diagnose GSAD. The symptomatic characteristics of the 
      GSAD patients were assessed with the Hamilton Anxiety Rating Scale, the Beck 
      Anxiety Inventory, the Retrospective Self Report of Inhibition, the Spielberger 
      State-Trait Anxiety Inventory, and the Liebowitz Social Anxiety Scale. RESULTS: 
      There were no significant differences in the frequencies of the genotypes 
      (chi(2)=0.961, degree of freedom [df]=2, p=0.619), alleles (chi(2)=0.415, df=1, 
      p=0.519), or allele (methionine) carriers (chi(2)=0.019, df=1, p=0.889) between the 
      patients and controls. In addition, when we compared the severity of social 
      anxiety symptom as determined by the clinical scales with the genotypes of the 
      BDNF gene, we could not find any significant differences between the genotypes or 
      allele carriers. CONCLUSION: These results do not support the hypothesis that the 
      BDNF gene might be a candidate gene for susceptibility or severity of GSAD in the 
      Korean population in this study.
FAU - Park, Jin-Sung
AU  - Park JS
AD  - Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Lim, Sewon
AU  - Lim S
FAU - Ha, Juwon
AU  - Ha J
FAU - Lee, Min-Soo
AU  - Lee MS
FAU - Oh, Kang-Seob
AU  - Oh KS
LA  - eng
PT  - Journal Article
DEP - 20111231
PL  - Korea (South)
TA  - Clin Psychopharmacol Neurosci
JT  - Clinical psychopharmacology and neuroscience : the official scientific journal of 
      the Korean College of Neuropsychopharmacology
JID - 101207332
PMC - PMC3569117
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Polymorphism
OT  - Social anxiety disorder
EDAT- 2011/12/01 00:00
MHDA- 2011/12/01 00:01
PMCR- 2011/12/01
CRDT- 2013/02/23 06:00
PHST- 2011/08/04 00:00 [received]
PHST- 2011/11/03 00:00 [revised]
PHST- 2011/11/14 00:00 [accepted]
PHST- 2013/02/23 06:00 [entrez]
PHST- 2011/12/01 00:00 [pubmed]
PHST- 2011/12/01 00:01 [medline]
PHST- 2011/12/01 00:00 [pmc-release]
AID - 10.9758/cpn.2011.9.3.129 [doi]
PST - ppublish
SO  - Clin Psychopharmacol Neurosci. 2011 Dec;9(3):129-33. doi: 
      10.9758/cpn.2011.9.3.129. Epub 2011 Dec 31.