PMID- 23430274
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130225
LR  - 20211021
IS  - 1738-1088 (Print)
IS  - 2093-4327 (Electronic)
IS  - 1738-1088 (Linking)
VI  - 10
IP  - 3
DP  - 2012 Dec
TI  - Association of the Brain-derived Neurotrophic Factor Gene and Clinical Features 
      of Bipolar Disorder in Korea.
PG  - 163-7
LID - 10.9758/cpn.2012.10.3.163 [doi]
AB  - OBJECTIVE: Brain-derived neurotrophic factor (BDNF) plays an important role in 
      cell survival, differentiation, and cell death as well as in neural plasticity. 
      Recent studies have suggested that BDNF is involved in the pathogenesis of 
      bipolar disorder. The aim of this study was to investigate the association of the 
      genetic variations of the BDNF gene with bipolar disorder in Korea. We also 
      studied the possible association of these genetic variants with clinical 
      features. METHODS: The allelic and genotypic distributions of Val66Met 
      polymorphism of the BDNF gene were analyzed using a polymerase chain 
      reaction-based method in 184 bipolar patients and 214 controls. Analysis was 
      performed to investigate an association of the Val66Met polymorphism of the BDNF 
      gene and the clinical features in bipolar patients. RESULTS: No significant 
      difference was found between bipolar patients and controls in the genotype and 
      allele frequencies for the investigated BDNF polymorphism. However, the age of 
      onset of bipolar disorder among the Val/Val (25.57), Val/Met (30.42) and Met/Met 
      (32.45) genotype groups were significantly different (p=0.037). CONCLUSION: This 
      study suggests that Val66Met polymorphisms are unlikely to contribution to the 
      genetic predisposition to bipolar disorder as a whole. But Val66Met polymorphism 
      may be associated with age of onset of the disorder, further studies designed to 
      investigate the relationship in a larger population may be warranted.
FAU - Min, Hye Ji
AU  - Min HJ
AD  - Department of Psychiatry, Hallym University College of Medicine, Anyang, Korea.
FAU - Cho, Hyun-Sang
AU  - Cho HS
FAU - Kim, Se Joo
AU  - Kim SJ
FAU - Seok, Jeong-Ho
AU  - Seok JH
FAU - Lee, Eun
AU  - Lee E
FAU - Jon, Duk-In
AU  - Jon DI
LA  - eng
PT  - Journal Article
DEP - 20121220
PL  - Korea (South)
TA  - Clin Psychopharmacol Neurosci
JT  - Clinical psychopharmacology and neuroscience : the official scientific journal of 
      the Korean College of Neuropsychopharmacology
JID - 101207332
PMC - PMC3569161
OTO - NOTNLM
OT  - Age of onset
OT  - Bipolar disorder
OT  - Brain-derived neurotrophic factor
OT  - Polymorphism
EDAT- 2013/02/23 06:00
MHDA- 2013/02/23 06:01
PMCR- 2012/12/01
CRDT- 2013/02/23 06:00
PHST- 2012/03/28 00:00 [received]
PHST- 2012/06/15 00:00 [revised]
PHST- 2012/06/26 00:00 [accepted]
PHST- 2013/02/23 06:00 [entrez]
PHST- 2013/02/23 06:00 [pubmed]
PHST- 2013/02/23 06:01 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - 10.9758/cpn.2012.10.3.163 [doi]
PST - ppublish
SO  - Clin Psychopharmacol Neurosci. 2012 Dec;10(3):163-7. doi: 
      10.9758/cpn.2012.10.3.163. Epub 2012 Dec 20.