PMID- 23430731
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130225
LR  - 20220316
IS  - 1738-1088 (Print)
IS  - 2093-4327 (Electronic)
IS  - 1738-1088 (Linking)
VI  - 10
IP  - 2
DP  - 2012 Aug
TI  - Effects of the antioxidant sulforaphane on hyperlocomotion and prepulse 
      inhibition deficits in mice after phencyclidine administration.
PG  - 94-8
LID - 10.9758/cpn.2012.10.2.94 [doi]
AB  - OBJECTIVE: Accumulating evidence suggests that oxidative stress plays a role in 
      the pathophysiology of schizophrenia and that the potent antioxidants may be 
      potential therapeutic drugs for schizophrenia. This study was undertaken to 
      examine the effects of the potent antioxidant sulforaphane (SFN), found in 
      cruciferous vegetables, on behavioral abnormalities (e.g., hyperlocomotion and 
      prepulse inhibition [PPI] deficits) in mice after a single administration of the 
      N-methyl-D-aspartate (NMDA)-receptor antagonist phencyclidine (PCP). METHODS: 
      Effects of SFN (3, 10, and 30 mg/kg, intraperitoneally [i.p.]) on hyperlocomotion 
      and PPI deficits in the adult male ddY mice after administration of PCP (3.0 
      mg/kg, subcutaneously [s.c.]) were examined. RESULTS: Administration of SFN (30 
      mg/kg, intraperitoneally [i.p.]), but not low doses (3 and 10 mg/kg, i.p.), 
      significantly attenuated hyperlocomotion in mice after PCP administration (3.0 
      mg/kg, subcutaneously [s.c.]). Furthermore, administration of SFN (3, 10, and 30 
      mg/kg, i.p.) attenuated the PPI deficits in mice after PCP administration (3.0 
      mg/kg, s.c.) in a dose-dependent manner. CONCLUSION: These results suggest that 
      SFN has antipsychotic activity in an animal model of schizophrenia. Therefore, it 
      is likely that SFN may be a potential therapeutic drug for schizophrenia.
FAU - Shirai, Yumi
AU  - Shirai Y
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, Japan.
FAU - Fujita, Yuko
AU  - Fujita Y
FAU - Hashimoto, Kenji
AU  - Hashimoto K
LA  - eng
PT  - Journal Article
DEP - 20120831
PL  - Korea (South)
TA  - Clin Psychopharmacol Neurosci
JT  - Clinical psychopharmacology and neuroscience : the official scientific journal of 
      the Korean College of Neuropsychopharmacology
JID - 101207332
PMC - PMC3569145
OTO - NOTNLM
OT  - Antioxidants
OT  - Nrf2 activator
OT  - Phencyclidine
OT  - Prepulse inhibition
OT  - Schizophrenia
OT  - Sulforaphane
EDAT- 2013/02/23 06:00
MHDA- 2013/02/23 06:01
PMCR- 2012/08/01
CRDT- 2013/02/23 06:00
PHST- 2012/03/21 00:00 [received]
PHST- 2012/04/21 00:00 [revised]
PHST- 2012/05/02 00:00 [accepted]
PHST- 2013/02/23 06:00 [entrez]
PHST- 2013/02/23 06:00 [pubmed]
PHST- 2013/02/23 06:01 [medline]
PHST- 2012/08/01 00:00 [pmc-release]
AID - 10.9758/cpn.2012.10.2.94 [doi]
PST - ppublish
SO  - Clin Psychopharmacol Neurosci. 2012 Aug;10(2):94-8. doi: 
      10.9758/cpn.2012.10.2.94. Epub 2012 Aug 31.