PMID- 23431394
OWN - NLM
STAT- MEDLINE
DCOM- 20130815
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 2
DP  - 2013
TI  - Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in Chinese 
      Han population independently of body mass index.
PG  - e56898
LID - 10.1371/journal.pone.0056898 [doi]
LID - e56898
AB  - Obesity and family history are the most important predictors for type 2 diabetes 
      mellitus(T2DM) in the Chinese Han population. However, it is not known whether 
      the genetic loci related to obesity are associated with the risk of developing 
      T2DM in this population. The present case-control study evaluated the 
      associations between five genetic loci for obesity and the pathogenesis of T2DM. 
      The study included 1117 Chinese Han patients with T2DM, 1629 patients with 
      pre-diabetes (impaired fasting glucose and impaired glucose tolerance, IFG/IGT) 
      and 1113 control subjects residing in Beijing. Five genetic loci including 
      rs2815752 near NEGR1, rs10938397 near GNPDA2, rs4074134 near BDNF, rs17782313 
      near MC4R and rs1084753 near KCTD15 were genotyped. The results showed an 
      association between rs4074134-BDNF minor allele and T2DM irrespective of age, 
      gender and body mass index (BMI) (OR = 0.87; 95%CI: 0.77-0.99, P = 0.04). This 
      SNP was also associated with pre-diabetes (OR = 0.87; 95%CI: 0.77-0.97, P = 0.01) 
      independently of age, gender and BMI. No associations were found between diabetes 
      or pre-diabetes and any of the other SNP loci studied. Genotype-phenotype 
      association analysis (adjusting for age and gender) showed rs4074134-BDNF to be 
      associated with BMI, waist circumference, fasting and postprandial plasma 
      glucose, fasting serum insulin, and HOMA-IR in subjects without T2DM. However, 
      fasting and postprandial plasma glucose were the only significant factors after 
      adjusting for BMI. These results suggest that the common variation of BDNF 
      (rs4074134) is associated with T2DM independently of obesity in Chinese Han 
      population. This variant also has an effect on plasma glucose concentration, BMI 
      and insulin sensitivity.
FAU - Han, Xueyao
AU  - Han X
AD  - Department of Endocrinology and Metabolism, Peking University People's Hospital, 
      Peking University Diabetes Center, Beijing, China.
FAU - Luo, Yingying
AU  - Luo Y
FAU - Zhang, Xiuying
AU  - Zhang X
FAU - Lv, Chao
AU  - Lv C
FAU - Sun, Xiuqin
AU  - Sun X
FAU - Zhang, Xiaomei
AU  - Zhang X
FAU - Zhou, Xianghai
AU  - Zhou X
FAU - Cai, Xiaoling
AU  - Cai X
FAU - Ren, Qian
AU  - Ren Q
FAU - Ji, Linong
AU  - Ji L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130219
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - *Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Obesity/genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Prediabetic State/genetics
MH  - Sequence Analysis, DNA
PMC - PMC3576386
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/02/23 06:00
MHDA- 2013/08/16 06:00
PMCR- 2013/02/19
CRDT- 2013/02/23 06:00
PHST- 2012/11/17 00:00 [received]
PHST- 2013/01/15 00:00 [accepted]
PHST- 2013/02/23 06:00 [entrez]
PHST- 2013/02/23 06:00 [pubmed]
PHST- 2013/08/16 06:00 [medline]
PHST- 2013/02/19 00:00 [pmc-release]
AID - PONE-D-12-36192 [pii]
AID - 10.1371/journal.pone.0056898 [doi]
PST - ppublish
SO  - PLoS One. 2013;8(2):e56898. doi: 10.1371/journal.pone.0056898. Epub 2013 Feb 19.