PMID- 23433799
OWN - NLM
STAT- MEDLINE
DCOM- 20130611
LR  - 20181202
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 86
IP  - 1
DP  - 2013 May 1
TI  - A population-based study of the fractionation of postlumpectomy breast radiation 
      therapy.
PG  - 51-7
LID - S0360-3016(12)03911-9 [pii]
LID - 10.1016/j.ijrobp.2012.12.015 [doi]
AB  - PURPOSE: The optimal fractionation schedule of post lumpectomy radiation therapy 
      remains controversial. The objective of this study was to describe the 
      fractionation of post-lumpectomy radiation therapy (RT) in Ontario, before and 
      after the seminal Ontario Clinical Oncology Group (OCOG) trial, which showed the 
      equivalence of 16- and 25-fraction schedules. METHODS AND MATERIALS: This was a 
      retrospective cohort study conducted by linking electronic treatment records to a 
      population-based cancer registry. The study population included all patients who 
      underwent lumpectomy for invasive breast cancer in Ontario, Canada, between 1984 
      and 2008. RESULTS: Over the study period, 41,747 breast cancer patients received 
      post lumpectomy radiation therapy to the breast only. Both 16- and 25-fraction 
      schedules were commonly used throughout the study period. In the early 1980s, 
      shorter fractionation schedules were used in >80% of cases. Between 1985 and 
      1995, the proportion of patients treated with shorter fractionation decreased to 
      48%. After completion of the OCOG trial, shorter fractionation schemes were once 
      again widely adopted across Ontario, and are currently used in about 71% of 
      cases; however, large intercenter variations in fractionation persisted. 
      CONCLUSIONS: The use of shorter schedules of post lumpectomy RT in Ontario 
      increased after completion of the OCOG trial, but the trial had a less normative 
      effect on practice than expected.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Ashworth, Allison
AU  - Ashworth A
AD  - Division of Cancer Care and Epidemiology, Queen's University Cancer Research 
      Institute, Kingston, Ontario, Canada.
FAU - Kong, Weidong
AU  - Kong W
FAU - Whelan, Timothy
AU  - Whelan T
FAU - Mackillop, William J
AU  - Mackillop WJ
LA  - eng
PT  - Journal Article
DEP - 20130220
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
CIN - Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):632-3. PMID: 24138908
CIN - Int J Radiat Oncol Biol Phys. 2013 Nov 15;87(4):633. PMID: 24138910
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/epidemiology/*radiotherapy/surgery
MH  - *Dose Fractionation, Radiation
MH  - Female
MH  - Health Services Accessibility/statistics & numerical data
MH  - Humans
MH  - *Mastectomy, Segmental/statistics & numerical data
MH  - *Medical Record Linkage
MH  - Middle Aged
MH  - Ontario/epidemiology
MH  - Postoperative Care/statistics & numerical data
MH  - Radiotherapy, Adjuvant/statistics & numerical data
MH  - Randomized Controlled Trials as Topic
MH  - *Registries
MH  - Regression Analysis
MH  - Retrospective Studies
EDAT- 2013/02/26 06:00
MHDA- 2013/06/12 06:00
CRDT- 2013/02/26 06:00
PHST- 2012/07/31 00:00 [received]
PHST- 2012/11/23 00:00 [revised]
PHST- 2012/12/18 00:00 [accepted]
PHST- 2013/02/26 06:00 [entrez]
PHST- 2013/02/26 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - S0360-3016(12)03911-9 [pii]
AID - 10.1016/j.ijrobp.2012.12.015 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2013 May 1;86(1):51-7. doi: 
      10.1016/j.ijrobp.2012.12.015. Epub 2013 Feb 20.