PMID- 23434101
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20181202
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 81
IP  - 4
DP  - 2013 Apr
TI  - Topical anesthetic agents for premature ejaculation: a systematic review and 
      meta-analysis.
PG  - 799-804
LID - S0090-4295(12)01572-5 [pii]
LID - 10.1016/j.urology.2012.12.028 [doi]
AB  - OBJECTIVE: To evaluate the efficacy and safety of topical anesthetic agents for 
      patients with premature ejaculation (PE). METHODS: Eligible randomized controlled 
      trials (RCTs) were identified from electronic databases (Cochrane Central 
      Register of Controlled Trials, Medline, and EMBASE) without language 
      restrictions. The database search, quality assessment, and data extraction were 
      performed independently by 2 reviewers. The main outcome for the efficacy of 
      topical anesthetic agents was intravaginal ejaculatory latency time (IELT). 
      Efficacy and safety were explored using Review Manager, version 5.1.0 (Cochrane 
      Collaboration, Oxford, UK). RESULTS: Eight trials met the inclusion criteria. Our 
      pooled analysis showed that IELT in the topical anesthetic agent group was 
      significantly improved compared to the placebo group (random-effect model; mean 
      difference [MD] 5.82, 95% confidence interval [CI] 3.50-8.14, P <.00001). 
      According to the subgroup analysis, a significant improvement was obtained in the 
      domains of ejaculatory control, sexual satisfaction, and distress in the Index of 
      Premature Ejaculation (IPE) questionnaire (random-effect model, MD 4.53, 95% CI 
      3.05-6.01, P <.00001). In terms of adverse events (AEs), the pooling outcome 
      showed that the overall incidence of AEs was significantly higher in the topical 
      anesthetic agent group than in the placebo group (random-effect model, relative 
      risk [RR] 4.28, 95% CI 1.63-11.24, P = .003). However, nearly all of the AEs were 
      mild and transient. CONCLUSION: Topical anesthetic agents have been shown to be 
      effective and well tolerated for patients with primary PE, providing a 
      significant improvement in IELT with a higher incidence of AEs that were not 
      long-lasting or severe. High-quality RCTs are necessary to confirm the efficacy 
      and safety of topical anesthetics for PE.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Pu, Chunxiao
AU  - Pu C
AD  - Department of Urology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Yang, Lu
AU  - Yang L
FAU - Liu, Liangren
AU  - Liu L
FAU - Yuan, Haichao
AU  - Yuan H
FAU - Wei, Qiang
AU  - Wei Q
FAU - Han, Ping
AU  - Han P
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20130220
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
RN  - 0 (Anesthetics, Local)
SB  - IM
MH  - Anesthetics, Local/*therapeutic use
MH  - Humans
MH  - Male
MH  - Premature Ejaculation/*drug therapy
MH  - Randomized Controlled Trials as Topic
EDAT- 2013/02/26 06:00
MHDA- 2013/06/19 06:00
CRDT- 2013/02/26 06:00
PHST- 2012/10/13 00:00 [received]
PHST- 2012/12/12 00:00 [revised]
PHST- 2012/12/20 00:00 [accepted]
PHST- 2013/02/26 06:00 [entrez]
PHST- 2013/02/26 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - S0090-4295(12)01572-5 [pii]
AID - 10.1016/j.urology.2012.12.028 [doi]
PST - ppublish
SO  - Urology. 2013 Apr;81(4):799-804. doi: 10.1016/j.urology.2012.12.028. Epub 2013 
      Feb 20.