PMID- 23434109
OWN - NLM
STAT- MEDLINE
DCOM- 20140116
LR  - 20130510
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 29
IP  - 6
DP  - 2013 Jun
TI  - The effect of hyperhomocysteinemia on aortic distensibility in healthy 
      individuals.
PG  - 876-80
LID - S0899-9007(13)00015-4 [pii]
LID - 10.1016/j.nut.2012.12.026 [doi]
AB  - OBJECTIVE: Elevated plasma homocysteine (HCY) levels have been associated with 
      increased risk for cardiovascular disease. Aortic distensibility and aortic pulse 
      wave velocity (PWV) are indices of aortic elasticity. The potential effect of 
      acute hyperhomocysteinemia (HHCY) on the elastic properties of the aorta in 
      healthy individuals is not known. The aim of the present study was to determine 
      the effect of acute methionine-induced HHCY on aortic distensibility and PWV in 
      healthy individualsand the effect of acute HHCY on myocardial performance of the 
      left ventricle (Tei index). METHODS: Thirty healthy volunteers were included in 
      this crossover study. An oral methionine (100 mg/kg) or water load was given in 
      random order on separate days at weekly intervals. Aortic distensibility and Tei 
      index were determined non-invasively by ultrasonography at baseline and 3 h after 
      methionine or water consumption, while PWV was measured by applanation tonometry 
      at baseline and every 1 h for the same time interval. RESULTS: Oral methionine 
      induced an increase in total plasma HCY concentrations (P < 0.001), whereas HCY 
      concentrations did not change after water consumption. Aortic distensibility 
      decreased 3 h after methionine load (P < 0.001) and Tei index increased 
      (P < 0.001), suggesting worsening compared with baseline values. Water 
      consumption had no effect on aortic distensibility or Tei index values. PWV 
      values did not change after either methionine or water consumption. CONCLUSIONS: 
      Acute methionine-induced HHCY reduces aortic distensibility and worsens 
      myocardial performance in healthy individuals. Further research is warranted to 
      examine in the long term the direct effects of HHCY on cardiovascular function 
      and the indirect effects on structural remodeling.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Eleftheriadou, Ioanna
AU  - Eleftheriadou I
AD  - First Department of Propaedeutic and Internal Medicine, Athens University Medical 
      School, Athens, Greece.
FAU - Grigoropoulou, Pinelopi
AU  - Grigoropoulou P
FAU - Moyssakis, Ioannis
AU  - Moyssakis I
FAU - Kokkinos, Alexandros
AU  - Kokkinos A
FAU - Perrea, Despoina
AU  - Perrea D
FAU - Toutouzas, Konstantinos
AU  - Toutouzas K
FAU - Katsilambros, Nicholas
AU  - Katsilambros N
FAU - Tentolouris, Nicholas
AU  - Tentolouris N
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130221
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aorta/*drug effects/*physiopathology
MH  - Blood Pressure/drug effects
MH  - Cardiovascular Diseases/etiology/physiopathology
MH  - Cross-Over Studies
MH  - Elasticity/drug effects
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/complications/*physiopathology
MH  - Male
MH  - Methionine/administration & dosage
MH  - Middle Aged
MH  - Pulse Wave Analysis
EDAT- 2013/02/26 06:00
MHDA- 2014/01/17 06:00
CRDT- 2013/02/26 06:00
PHST- 2012/07/16 00:00 [received]
PHST- 2012/12/05 00:00 [revised]
PHST- 2012/12/31 00:00 [accepted]
PHST- 2013/02/26 06:00 [entrez]
PHST- 2013/02/26 06:00 [pubmed]
PHST- 2014/01/17 06:00 [medline]
AID - S0899-9007(13)00015-4 [pii]
AID - 10.1016/j.nut.2012.12.026 [doi]
PST - ppublish
SO  - Nutrition. 2013 Jun;29(6):876-80. doi: 10.1016/j.nut.2012.12.026. Epub 2013 Feb 
      21.