PMID- 23434505
OWN - NLM
STAT- MEDLINE
DCOM- 20131025
LR  - 20231106
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 146
IP  - 1-3
DP  - 2013 May
TI  - Change in neuropsychological functioning over one year in youth at clinical high 
      risk for psychosis.
PG  - 87-94
LID - S0920-9964(13)00055-8 [pii]
LID - 10.1016/j.schres.2013.01.017 [doi]
AB  - Schizophrenia and related psychotic disorders are associated with significant 
      neuropsychological (NP) impairments. Yet the onset and developmental evolution of 
      these impairments remains incompletely characterized. This study examined NP 
      functioning over one year in a sample of youth at clinical high risk (CHR) for 
      psychosis participating in a treatment study. We assessed functioning across six 
      cognitive domains at two time points in a sample of 53 CHR and 32 healthy 
      comparison (HC) subjects. Linear regression of HC one-year scores was used to 
      predict one-year performance for CHR from baseline scores and relevant 
      demographic variables. We used raw scores and MANOVAs of the standardized 
      residuals to test for progressive impairment over time. NP functioning of CHR at 
      one year fell significantly below predicted levels. Effects were largest and most 
      consistent for a failure of normative improvement on tests of executive function. 
      CHR who reached the highest positive symptom rating (6, severe and psychotic) on 
      the Structured Interview of Prodromal Syndromes after the baseline assessment (n 
      = 10/53) demonstrated a particularly large (d = -1.89), although non-significant, 
      discrepancy between observed and predicted one-year verbal memory test 
      performance. Findings suggest that, although much of the cognitive impairment 
      associated with psychosis is present prior to the full expression of the 
      psychotic syndrome, some progressive NP impairments may accompany risk for 
      psychosis and be greatest for those who develop psychotic level symptoms.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Woodberry, Kristen A
AU  - Woodberry KA
AD  - Department of Psychiatry, Beth Israel Deaconess Medical Center, United States. 
      kwoodber@bidmc.harvard.edu
FAU - McFarlane, William R
AU  - McFarlane WR
FAU - Giuliano, Anthony J
AU  - Giuliano AJ
FAU - Verdi, Mary B
AU  - Verdi MB
FAU - Cook, William L
AU  - Cook WL
FAU - Faraone, Stephen V
AU  - Faraone SV
FAU - Seidman, Larry J
AU  - Seidman LJ
LA  - eng
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - R01 MH065367/MH/NIMH NIH HHS/United States
GR  - NIMH RO1MH065367/PHS HHS/United States
GR  - NIMH 1 U01 MH081928-01A1/PHS HHS/United States
GR  - NIMH P50 MH080272-02/PHS HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130222
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Child
MH  - Cognition Disorders/*etiology/therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Neuropsychological Tests
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*complications/*psychology
MH  - Young Adult
PMC - PMC3633465
MID - NIHMS449292
EDAT- 2013/02/26 06:00
MHDA- 2013/10/26 06:00
PMCR- 2014/05/01
CRDT- 2013/02/26 06:00
PHST- 2012/08/21 00:00 [received]
PHST- 2013/01/08 00:00 [revised]
PHST- 2013/01/10 00:00 [accepted]
PHST- 2013/02/26 06:00 [entrez]
PHST- 2013/02/26 06:00 [pubmed]
PHST- 2013/10/26 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - S0920-9964(13)00055-8 [pii]
AID - 10.1016/j.schres.2013.01.017 [doi]
PST - ppublish
SO  - Schizophr Res. 2013 May;146(1-3):87-94. doi: 10.1016/j.schres.2013.01.017. Epub 
      2013 Feb 22.