PMID- 23435120
OWN - NLM
STAT- MEDLINE
DCOM- 20130509
LR  - 20221207
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 14
IP  - 4
DP  - 2013 Apr
TI  - The transcription factor STAT5 is critical in dendritic cells for the development 
      of TH2 but not TH1 responses.
PG  - 364-71
LID - 10.1038/ni.2541 [doi]
AB  - Dendritic cells (DCs) are critical in immune responses, linking innate and 
      adaptive immunity. We found here that DC-specific deletion of the transcription 
      factor STAT5 was not critical for development but was required for T helper type 
      2 (TH2), but not TH1, allergic responses in both the skin and lungs. Loss of 
      STAT5 in DCs led to the inability to respond to thymic stromal lymphopoietin 
      (TSLP). STAT5 was required for TSLP-dependent DC activation, including 
      upregulation of the expression of costimulatory molecules and chemokine 
      production. Furthermore, TH2 responses in mice with DC-specific loss of STAT5 
      resembled those seen in mice deficient in the receptor for TSLP. Our results show 
      that the TSLP-STAT5 axis in DCs is a critical component for the promotion of type 
      2 immunity at barrier surfaces.
FAU - Bell, Bryan D
AU  - Bell BD
AD  - Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, 
      Washington, USA.
FAU - Kitajima, Masayuki
AU  - Kitajima M
FAU - Larson, Ryan P
AU  - Larson RP
FAU - Stoklasek, Thomas A
AU  - Stoklasek TA
FAU - Dang, Kristen
AU  - Dang K
FAU - Sakamoto, Kazuhito
AU  - Sakamoto K
FAU - Wagner, Kay-Uwe
AU  - Wagner KU
FAU - Kaplan, Daniel H
AU  - Kaplan DH
FAU - Reizis, Boris
AU  - Reizis B
FAU - Hennighausen, Lothar
AU  - Hennighausen L
FAU - Ziegler, Steven F
AU  - Ziegler SF
LA  - eng
GR  - R01 AR055695/AR/NIAMS NIH HHS/United States
GR  - P01 HL098067/HL/NHLBI NIH HHS/United States
GR  - R01 AI068731/AI/NIAID NIH HHS/United States
GR  - R01-AR055695/AR/NIAMS NIH HHS/United States
GR  - R01 AR056113/AR/NIAMS NIH HHS/United States
GR  - R01-AI068731/AI/NIAID NIH HHS/United States
GR  - R01-AR056113/AR/NIAMS NIH HHS/United States
GR  - P01-HL098067/HL/NHLBI NIH HHS/United States
GR  - T32 AI007411/AI/NIAID NIH HHS/United States
GR  - 5T32AI007411-19/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130224
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Cytokines)
RN  - 0 (STAT5 Transcription Factor)
RN  - EC 2.7.10.2 (Janus Kinases)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
RN  - 0 (TSLP protein, mouse)
SB  - IM
EIN - Nat Immunol. 2014 Mar;15(3):305. Kaplan, Daniel H [added]
MH  - Animals
MH  - Cell Differentiation
MH  - Cytokines/immunology/metabolism
MH  - Dendritic Cells/cytology/*immunology/*metabolism
MH  - Dermatitis, Contact/immunology/metabolism
MH  - Dermis/immunology/metabolism
MH  - Female
MH  - Homeostasis/immunology
MH  - Janus Kinases/metabolism
MH  - Lung/immunology/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - STAT5 Transcription Factor/genetics/*metabolism
MH  - Signal Transduction
MH  - Th1 Cells/immunology
MH  - Th2 Cells/*immunology
MH  - Thymic Stromal Lymphopoietin
PMC - PMC4161284
MID - NIHMS434147
EDAT- 2013/02/26 06:00
MHDA- 2013/05/10 06:00
PMCR- 2014/09/11
CRDT- 2013/02/26 06:00
PHST- 2012/09/13 00:00 [received]
PHST- 2013/01/08 00:00 [accepted]
PHST- 2013/02/26 06:00 [entrez]
PHST- 2013/02/26 06:00 [pubmed]
PHST- 2013/05/10 06:00 [medline]
PHST- 2014/09/11 00:00 [pmc-release]
AID - ni.2541 [pii]
AID - 10.1038/ni.2541 [doi]
PST - ppublish
SO  - Nat Immunol. 2013 Apr;14(4):364-71. doi: 10.1038/ni.2541. Epub 2013 Feb 24.