PMID- 23435747
OWN - NLM
STAT- MEDLINE
DCOM- 20130828
LR  - 20211021
IS  - 1534-312X (Electronic)
IS  - 1522-8037 (Linking)
VI  - 15
IP  - 4
DP  - 2013 Apr
TI  - Extra-esophageal manifestations of GERD: who responds to GERD therapy?
PG  - 318
LID - 10.1007/s11894-013-0318-4 [doi]
AB  - Gastroesophageal reflux disease (GERD) is a common disease that is defined as a 
      condition that develops when the reflux of stomach contents causes troublesome 
      symptoms. In addition to the esophageal manifestations of heartburn and 
      regurgitation, the role of GERD in causing extra-esophageal symptoms, such as 
      laryngitis, asthma, cough, chest pain, and dental erosions, is increasingly 
      recognized with renewed interest. Due to the poor sensitivity of endoscopy and pH 
      monitoring, and the poor specificity of laryngoscopy, empiric therapy with proton 
      pump inhibitors (PPI) is now considered the initial diagnostic step in patients 
      suspected of having GERD-related symptoms. In those who are unresponsive to such 
      therapy, other diagnostic testing such as impedance/pH monitoring may be 
      reasonable in order to exclude continued acid or weakly acid reflux. Recent data 
      suggest that patients with extra-esophageal symptoms who have concomitant typical 
      symptoms, moderate-sized hiatal hernia and moderate reflux on pH testing may 
      respond better to acid suppressive therapy. This group only accounts for 20-30 % 
      of patients commonly referred for suspected GERD. PPI-unresponsive patients 
      usually have causes other than GERD for their extra-esophageal signs and symptoms 
      and continued PPI therapy in this group is not recommended.
FAU - Naik, Rishi D
AU  - Naik RD
AD  - Division of Gastroenterology, Hepatology, and Nutrition, Center for Swallowing 
      and Esophageal Disorders, Digestive Disease Center, Vanderbilt University Medical 
      Center, Nashville, TN 37232-5280, USA.
FAU - Vaezi, Michael F
AU  - Vaezi MF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Gastroenterol Rep
JT  - Current gastroenterology reports
JID - 100888896
SB  - IM
MH  - Asthma/etiology
MH  - Chest Pain/etiology
MH  - Chronic Disease
MH  - Cough/etiology
MH  - Gastroesophageal Reflux/*complications/diagnosis/therapy
MH  - Humans
MH  - Laryngitis/etiology
EDAT- 2013/02/26 06:00
MHDA- 2013/08/29 06:00
CRDT- 2013/02/26 06:00
PHST- 2013/02/26 06:00 [entrez]
PHST- 2013/02/26 06:00 [pubmed]
PHST- 2013/08/29 06:00 [medline]
AID - 10.1007/s11894-013-0318-4 [doi]
PST - ppublish
SO  - Curr Gastroenterol Rep. 2013 Apr;15(4):318. doi: 10.1007/s11894-013-0318-4.