PMID- 23436039
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20211021
IS  - 1863-6713 (Electronic)
IS  - 1863-6705 (Linking)
VI  - 61
IP  - 7
DP  - 2013 Jul
TI  - Venovenous extracorporeal membrane oxygenation is effective against 
      post-cardiotomy acute respiratory failure in adults.
PG  - 402-8
LID - 10.1007/s11748-013-0226-4 [doi]
AB  - BACKGROUND: Acute respiratory failure is a serious issue that occasionally occurs 
      after weaning from cardiopulmonary bypass (CPB) after heart surgery. This 
      condition can be refractory to mechanical ventilation and the mortality rate is 
      high. Venovenous extracorporeal membrane oxygenation (VV-ECMO) is applied to 
      treat acute lung failure after CPB at our institution. This report describes the 
      use of VV-ECMO after cardiac surgery at a single institution. METHODS: We 
      analyzed the outcomes of 11 patients who developed severe acute respiratory 
      failure requiring VV-ECMO after undergoing heart surgery with a cardiopulmonary 
      bypass. RESULTS: Four (36.4%) patients died in hospital. One patient required 
      conversion from VV- to venoarterial (VA-) ECMO because of circulatory 
      instability. One patient each died of respiratory failure and heart failure and 
      two died of ischemic colitis. Lung damage secondarily developed in these four 
      patients to other disabled organs. Seven (63.6%) patients whose lungs were 
      primarily disabled were weaned from VV-ECMO upon recovery from respiratory 
      failure and were ambulatory at the time of discharge from hospital. The ratio of 
      PaO2/FIO2 (P/F) at 24 h after starting VV-ECMO did not significantly differ 
      between survivors and non-survivors (187.9 +/- 57.7 vs. 135.5 +/- 20.5, p = 0.10), 
      but tended to be higher in survivors. Non-survivors were significantly older than 
      survivors. CONCLUSION: Patients who develop severe acute respiratory failure 
      after undergoing heart surgery using cardiopulmonary bypass derive a survival 
      benefit from VV-ECMO.
FAU - Nakamura, Hiromasa
AU  - Nakamura H
AD  - Department of Cardiovascular Surgery, New Tokyo Hospital, 473-1 Nemoto, Matsudo 
      City, Chiba 271-0077, Japan. kinakamurah@gmail.com
FAU - Yamaguchi, Hiroki
AU  - Yamaguchi H
FAU - Amano, Atsushi
AU  - Amano A
FAU - Nakao, Tatsuya
AU  - Nakao T
LA  - eng
PT  - Journal Article
DEP - 20130224
PL  - Japan
TA  - Gen Thorac Cardiovasc Surg
JT  - General thoracic and cardiovascular surgery
JID - 101303952
SB  - IM
MH  - Acute Lung Injury/etiology/*therapy
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiac Surgical Procedures/adverse effects
MH  - Cardiopulmonary Bypass/*adverse effects
MH  - Cardiovascular Diseases/surgery
MH  - *Extracorporeal Membrane Oxygenation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Respiratory Insufficiency/etiology/*therapy
EDAT- 2013/02/26 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/02/26 06:00
PHST- 2012/11/17 00:00 [received]
PHST- 2013/02/12 00:00 [accepted]
PHST- 2013/02/26 06:00 [entrez]
PHST- 2013/02/26 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11748-013-0226-4 [doi]
PST - ppublish
SO  - Gen Thorac Cardiovasc Surg. 2013 Jul;61(7):402-8. doi: 10.1007/s11748-013-0226-4. 
      Epub 2013 Feb 24.