PMID- 23436340
OWN - NLM
STAT- MEDLINE
DCOM- 20131101
LR  - 20220321
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 29
IP  - 5
DP  - 2013 Jul
TI  - The important role of physical activity in the prevention and management of 
      gestational diabetes mellitus.
PG  - 334-46
LID - 10.1002/dmrr.2402 [doi]
AB  - The actual pathophysiology behind gestational diabetes mellitus (GDM) is still 
      unclear, but a deterioration in insulin resistance beyond that induced by 
      pregnancy, combined with beta cell dysfunction, plays a key role. Interventions 
      that help improve glucose tolerance by attenuating pregnancy-induced insulin 
      resistance or achieve glycaemic control may therefore help in preventing and 
      managing GDM. In non-pregnant populations, physical activity has been associated 
      with an improvement in glucose homeostasis and insulin sensitivity and a risk 
      reduction for type 2 diabetes mellitus (T2DM) and is a cornerstone for T2DM 
      treatment. However, there is still controversy regarding the benefits of physical 
      activity in preventing and managing GDM. The objective of this review is 
      therefore to provide a comprehensive overview of the effect of prenatal physical 
      activity-based interventions on (1) glucose tolerance, insulin sensitivity and 
      GDM prevention and (2) glycaemic control and insulin use in GDM women. On the 
      basis of the available literature, there is a lack of consistent evidence 
      regarding the benefits of physical activity on improving glucose tolerance and 
      insulin sensitivity and preventing GDM. However, it appears that physical 
      activity may help to achieve good glycaemic control and limit insulin use in GDM 
      women. Compliance appears to be a major problem in physical activity-based 
      intervention studies aimed at GDM prevention. Rigorous scientific research is 
      still required to make an informed decision about the role of physical activity 
      in the prevention and management of GDM and to develop evidence-based physical 
      activity guidelines for GDM prevention and management.
CI  - Copyright (c) 2013 John Wiley & Sons, Ltd.
FAU - Ruchat, Stephanie-May
AU  - Ruchat SM
AD  - R. Samuel McLaughlin Foundation, Exercise and Pregnancy Laboratory, School of 
      Kinesiology, The University of Western Ontario, London, ON, Canada. 
      steph_ruchat@hotmail.com
FAU - Mottola, Michelle F
AU  - Mottola MF
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
SB  - IM
MH  - Combined Modality Therapy
MH  - Diabetes, Gestational/*prevention & control/therapy
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Life Style
MH  - *Motor Activity
MH  - Pregnancy
OTO - NOTNLM
OT  - gestational diabetes
OT  - intervention
OT  - management
OT  - physical activity
OT  - pregnancy
OT  - prevention
EDAT- 2013/02/26 06:00
MHDA- 2013/11/02 06:00
CRDT- 2013/02/26 06:00
PHST- 2012/08/29 00:00 [received]
PHST- 2012/12/19 00:00 [revised]
PHST- 2013/01/27 00:00 [accepted]
PHST- 2013/02/26 06:00 [entrez]
PHST- 2013/02/26 06:00 [pubmed]
PHST- 2013/11/02 06:00 [medline]
AID - 10.1002/dmrr.2402 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2013 Jul;29(5):334-46. doi: 10.1002/dmrr.2402.