PMID- 23437344
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 2
DP  - 2013
TI  - SNPs identified as modulators of ECG traits in the general population do not 
      markedly affect ECG traits during acute myocardial infarction nor ventricular 
      fibrillation risk in this condition.
PG  - e57216
LID - 10.1371/journal.pone.0057216 [doi]
LID - e57216
AB  - BACKGROUND: Ventricular fibrillation (VF) in the setting of acute ST elevation 
      myocardial infarction (STEMI) is a leading cause of mortality. Although the risk 
      of VF has a genetic component, the underlying genetic factors are largely 
      unknown. Since heart rate and ECG intervals of conduction and repolarization 
      during acute STEMI differ between patients who do and patients who do not develop 
      VF, we investigated whether SNPs known to modulate these ECG indices in the 
      general population also impact on the respective ECG indices during STEMI and on 
      the risk of VF. METHODS AND RESULTS: The study population consisted of 
      participants of the Arrhythmia Genetics in the NEtherlandS (AGNES) study, which 
      enrols patients with a first STEMI that develop VF (cases) and patients that do 
      not develop VF (controls). SNPs known to impact on RR interval, PR interval, QRS 
      duration or QTc interval in the general population were tested for effects on the 
      respective STEMI ECG indices (stage 1). Only those showing a (suggestive) 
      significant association were tested for association with VF (stage 2). On 
      average, VF cases had a shorter RR and a longer QTc interval compared to non-VF 
      controls. Eight SNPs showed a trend for association with the respective STEMI ECG 
      indices. Of these, three were also suggestively associated with VF. CONCLUSIONS: 
      RR interval and ECG indices of conduction and repolarization during acute STEMI 
      differ between patients who develop VF and patients who do not. Although the 
      effects of the SNPs on ECG indices during an acute STEMI seem to be similar in 
      magnitude and direction as those found in the general population, the effects, at 
      least in isolation, are too small to explain the differences in ECGs between 
      cases and controls and to determine risk of VF.
FAU - Pazoki, Raha
AU  - Pazoki R
AD  - Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Academic 
      Medical Center, Amsterdam, The Netherlands.
FAU - de Jong, Jonas S S G
AU  - de Jong JS
FAU - Marsman, Roos F
AU  - Marsman RF
FAU - Bruinsma, Nienke
AU  - Bruinsma N
FAU - Dekker, Lukas R C
AU  - Dekker LR
FAU - Wilde, Arthur A M
AU  - Wilde AA
FAU - Bezzina, Connie R
AU  - Bezzina CR
FAU - Tanck, Michael W T
AU  - Tanck MW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130220
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Electrocardiography
MH  - Female
MH  - *Genetic Loci
MH  - Genome-Wide Association Study
MH  - Heart Conduction System/metabolism/pathology
MH  - Heart Rate/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/*genetics/metabolism/pathology
MH  - Netherlands
MH  - *Polymorphism, Single Nucleotide
MH  - Risk
MH  - Ventricular Fibrillation/complications/*genetics/metabolism/pathology
PMC - PMC3577709
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/02/26 06:00
MHDA- 2013/08/07 06:00
PMCR- 2013/02/20
CRDT- 2013/02/26 06:00
PHST- 2012/06/25 00:00 [received]
PHST- 2013/01/22 00:00 [accepted]
PHST- 2013/02/26 06:00 [entrez]
PHST- 2013/02/26 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
PHST- 2013/02/20 00:00 [pmc-release]
AID - PONE-D-12-18339 [pii]
AID - 10.1371/journal.pone.0057216 [doi]
PST - ppublish
SO  - PLoS One. 2013;8(2):e57216. doi: 10.1371/journal.pone.0057216. Epub 2013 Feb 20.