PMID- 23438323
OWN - NLM
STAT- MEDLINE
DCOM- 20131211
LR  - 20220330
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 39
IP  - 5
DP  - 2013 May
TI  - Hypertensive pregnancy disorders as a risk factor for future cardiovascular and 
      metabolic disorders (Tehran Lipid and Glucose Study).
PG  - 891-7
LID - 10.1111/j.1447-0756.2012.02069.x [doi]
AB  - BACKGROUND: Although hypertensive pregnancy disorders (HPD) are common worldwide, 
      there is no consensus regarding their long-term cardiovascular and metabolic 
      consequences. We aimed to ascertain the association between HPD and the 
      development of cardiovascular and metabolic disturbances later in life. MATERIAL 
      AND METHODS: A cohort of 226 women with a history of HPD was selected as the case 
      group, and a group of 226 age- and body-mass-index-matched women, with no history 
      of HPD, was selected as controls. Both groups were selected from among 
      participants of the Tehran Lipid and Glucose Study and were compared for 
      concentrations of metabolic parameters and incidence of hypertension, type 2 
      diabetes mellitus (T2DM) and dyslipidemia over a follow up of 10 years. RESULTS: 
      Women with a history of HPD, compared with age- and body-mass-index-matched women 
      without such a history, had an increased risk of cardiovascular and metabolic 
      disorders, including a twofold increased risk for hypertension (95% confidence 
      interval [CI]: 1.4-3.2), a threefold increased risk for T2DM (95% CI: 1.8-5.2) 
      and a 1.3-fold increased risk for dyslipidemia (95% CI: 1.2-1.5). CONCLUSIONS: 
      Women with a history of hypertension in pregnancy are at increased risk for 
      subsequent diagnosis of hypertension, dyslipidemia and T2DM later in life. These 
      women may benefit from close monitoring and timely implementation of primary 
      prevention measures of cardiovascular and metabolic risk factors and lifestyle 
      modifications.
CI  - (c) 2013 The Authors. Journal of Obstetrics and Gynaecology Research (c) 2013 Japan 
      Society of Obstetrics and Gynecology.
FAU - Hashemi, Somayeh
AU  - Hashemi S
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
FAU - Ramezani Tehrani, Fahimeh
AU  - Ramezani Tehrani F
FAU - Mehrabi, Yadollah
AU  - Mehrabi Y
FAU - Azizi, Fereidoun
AU  - Azizi F
LA  - eng
PT  - Journal Article
DEP - 20130226
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
SB  - IM
MH  - Adult
MH  - Cardiovascular Diseases/epidemiology/*etiology
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Dyslipidemias/epidemiology/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypertension/epidemiology/etiology
MH  - Hypertension, Pregnancy-Induced/*physiopathology
MH  - Incidence
MH  - Iran/epidemiology
MH  - Lipid Metabolism Disorders/epidemiology/*etiology
MH  - Metabolic Diseases/epidemiology/*etiology
MH  - Middle Aged
MH  - Pregnancy
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 2013/02/27 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/02/27 06:00
PHST- 2012/04/15 00:00 [received]
PHST- 2012/09/18 00:00 [accepted]
PHST- 2013/02/27 06:00 [entrez]
PHST- 2013/02/27 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/j.1447-0756.2012.02069.x [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2013 May;39(5):891-7. doi: 
      10.1111/j.1447-0756.2012.02069.x. Epub 2013 Feb 26.