PMID- 23439322
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20231213
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 37
IP  - 11
DP  - 2013 Nov
TI  - Changes in human dendritic cell number and function in severe obesity may 
      contribute to increased susceptibility to viral infection.
PG  - 1510-3
LID - 10.1038/ijo.2013.16 [doi]
AB  - Dendritic cells (DCs) are key immune sentinels linking the innate and adaptive 
      immune systems. DCs recognise danger signals and initiate T-cell tolerance, 
      memory and polarisation. They are critical cells in responding to a viral 
      illness. Obese individuals have been shown to have an impaired response to 
      vaccinations against virally mediated conditions and to have an increased 
      susceptibility to multi-organ failure in response to viral illness. We 
      investigated if DCs are altered in an obese cohort (mean body mass index 
      51.7+/-7.3 kg m(-2)), ultimately resulting in differential T-cell responses. 
      Circulating DCs were found to be significantly decreased in the obese compared 
      with the lean cohort (0.82% vs 2.53%). Following Toll-like receptor stimulation, 
      compared with lean controls, DCs generated from the obese cohort upregulated 
      significantly less CD83 (40% vs 17% mean fluorescence intensity), a molecule 
      implicated in the elicitation of T-cell responses, particularly viral responses. 
      Obese DCs produced twofold more of the immunosuppressive cytokine interleukin 
      (IL)-10 than lean controls, and in turn stimulated fourfold more IL-4-production 
      from allogenic naive T cells. We conclude that obesity negatively impacts the 
      ability of DCs to mature and elicit appropriate T-cell responses to a general 
      stimulus. This may contribute to the increased susceptibility to viral infection 
      observed in severe obesity.
FAU - O'Shea, D
AU  - O'Shea D
AD  - 1] Obesity Immunology Group, Education and Research Centre, St Vincent's 
      University Hospital, University College Dublin, Dublin, Ireland [2] Department of 
      Endocrinology, St Columcille's Hospital, Health Service Executive, Loughlinstown, 
      Dublin, Ireland.
FAU - Corrigan, M
AU  - Corrigan M
FAU - Dunne, M R
AU  - Dunne MR
FAU - Jackson, R
AU  - Jackson R
FAU - Woods, C
AU  - Woods C
FAU - Gaoatswe, G
AU  - Gaoatswe G
FAU - Moynagh, P N
AU  - Moynagh PN
FAU - O'Connell, J
AU  - O'Connell J
FAU - Hogan, A E
AU  - Hogan AE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130226
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Antigens, CD)
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Vaccines)
RN  - 0 (Immunoglobulins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Tetanus Toxoid)
SB  - IM
MH  - Adult
MH  - Antigens, CD/*metabolism
MH  - Dendritic Cells/*immunology
MH  - Disease Susceptibility
MH  - Female
MH  - Flow Cytometry
MH  - Hepatitis B Antibodies/blood
MH  - Hepatitis B Vaccines/immunology
MH  - Humans
MH  - Immunity, Innate/*genetics
MH  - Immunoglobulins/*metabolism
MH  - Male
MH  - Membrane Glycoproteins/*metabolism
MH  - Obesity, Morbid/complications/*immunology
MH  - T-Lymphocytes/*immunology
MH  - Tetanus Toxoid/immunology
MH  - CD83 Antigen
EDAT- 2013/02/27 06:00
MHDA- 2014/07/17 06:00
CRDT- 2013/02/27 06:00
PHST- 2012/08/20 00:00 [received]
PHST- 2013/01/04 00:00 [revised]
PHST- 2013/01/09 00:00 [accepted]
PHST- 2013/02/27 06:00 [entrez]
PHST- 2013/02/27 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - ijo201316 [pii]
AID - 10.1038/ijo.2013.16 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2013 Nov;37(11):1510-3. doi: 10.1038/ijo.2013.16. Epub 2013 
      Feb 26.