PMID- 23439663 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20130227 LR - 20211021 IS - 1664-2295 (Print) IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 4 DP - 2013 TI - Late onset CNS immune reconstitution inflammatory syndrome in an immunocompetent patient. PG - 12 LID - 10.3389/fneur.2013.00012 [doi] LID - 12 AB - Immune reconstitution inflammatory syndrome (IRIS) refers to the presence of paradoxical clinical deterioration attributable to immune system recovery during highly active antiretroviral therapy (HAART). We present an immunocompetent patient with multifocal leukoencephalopathy on HAART, with central nervous system (CNS) IRIS pathology of unknown infectious etiology. CNS IRIS pathology should be suspected in patients on longstanding HAART without immune reconstitution, presenting with unexplained leukoencephalopathy. FAU - Hornik, Alejandro AU - Hornik A AD - Department of Neurology, Stritch School of Medicine, Loyola University Chicago Maywood, IL, USA. FAU - Rodriguez-Porcel, Federico AU - Rodriguez-Porcel F FAU - Wallery, Shawn AU - Wallery S FAU - Flaster, Murray AU - Flaster M FAU - Lee, John M AU - Lee JM FAU - Biller, Jose AU - Biller J LA - eng PT - Journal Article DEP - 20130221 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 PMC - PMC3578199 OTO - NOTNLM OT - AIDS OT - HIV OT - IRIS OT - multifocal leukoencephalopathy OT - seizures EDAT- 2013/02/27 06:00 MHDA- 2013/02/27 06:01 PMCR- 2013/02/21 CRDT- 2013/02/27 06:00 PHST- 2013/01/16 00:00 [received] PHST- 2013/02/02 00:00 [accepted] PHST- 2013/02/27 06:00 [entrez] PHST- 2013/02/27 06:00 [pubmed] PHST- 2013/02/27 06:01 [medline] PHST- 2013/02/21 00:00 [pmc-release] AID - 10.3389/fneur.2013.00012 [doi] PST - epublish SO - Front Neurol. 2013 Feb 21;4:12. doi: 10.3389/fneur.2013.00012. eCollection 2013.