PMID- 23440468
OWN - NLM
STAT- MEDLINE
DCOM- 20130912
LR  - 20211021
IS  - 1471-2970 (Electronic)
IS  - 0962-8436 (Print)
IS  - 0962-8436 (Linking)
VI  - 368
IP  - 1615
DP  - 2013
TI  - Anxiety and affective disorder comorbidity related to serotonin and other 
      neurotransmitter systems: obsessive-compulsive disorder as an example of 
      overlapping clinical and genetic heterogeneity.
PG  - 20120435
LID - 10.1098/rstb.2012.0435 [doi]
LID - 20120435
AB  - Individuals with obsessive-compulsive disorder (OCD) have also been shown to have 
      comorbid lifetime diagnoses of major depressive disorder (MDD; rates greater than 
      70%), bipolar disorder (rates greater than 10%) and other anxiety disorders (e.g. 
      panic disorder, post-traumatic stress disorder (PTSD)). In addition, overlap 
      exists in some common genetic variants (e.g. the serotonin transporter gene 
      (SLC6A4), the brain-derived neurotrophic factor (BDNF) gene), and rare variants 
      in genes/chromosomal abnormalities (e.g. the 22q11 microdeletion syndrome) found 
      across the affective/anxiety disorder spectrums. OCD has been proposed as a 
      possible independent entity for DSM-5, but by others thought best retained as an 
      anxiety disorder subtype (its current designation in DSM-IV), and yet by others 
      considered best in the affective disorder spectrum. This review focuses on OCD, a 
      well-studied but still puzzling heterogeneous disorder, regarding alterations in 
      serotonergic, dopaminergic and glutamatergic neurotransmission in addition to 
      other systems involved, and how related genes may be involved in the comorbidity 
      of anxiety and affective disorders. OCD resembles disorders such as depression, 
      in which gene x gene interactions, gene x environment interactions and stress 
      elements coalesce to yield OC symptoms and, in some individuals, full-blown OCD 
      with multiple comorbid disorders.
FAU - Murphy, Dennis L
AU  - Murphy DL
AD  - Laboratory of Clinical Science, National Institute of Mental Health, National 
      Institutes of Health, Bethesda, MD 20892, USA.
FAU - Moya, Pablo R
AU  - Moya PR
FAU - Fox, Meredith A
AU  - Fox MA
FAU - Rubenstein, Liza M
AU  - Rubenstein LM
FAU - Wendland, Jens R
AU  - Wendland JR
FAU - Timpano, Kiara R
AU  - Timpano KR
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20130225
PL  - England
TA  - Philos Trans R Soc Lond B Biol Sci
JT  - Philosophical transactions of the Royal Society of London. Series B, Biological 
      sciences
JID - 7503623
RN  - 0 (Excitatory Amino Acid Transporter 3)
RN  - 0 (Receptors, Serotonin, 5-HT1)
RN  - 0 (SLC1A1 protein, human)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
SB  - IM
MH  - Animals
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 22/genetics/metabolism
MH  - Comorbidity
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Excitatory Amino Acid Transporter 3/genetics/metabolism
MH  - Gene-Environment Interaction
MH  - *Genetic Heterogeneity
MH  - Humans
MH  - Mood Disorders/epidemiology/*genetics
MH  - Obsessive-Compulsive Disorder/epidemiology/*genetics/pathology
MH  - Receptors, Serotonin, 5-HT1/metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/genetics/metabolism
MH  - Synaptic Transmission
PMC - PMC3638387
EDAT- 2013/02/27 06:00
MHDA- 2013/09/13 06:00
PMCR- 2014/04/05
CRDT- 2013/02/27 06:00
PHST- 2013/02/27 06:00 [entrez]
PHST- 2013/02/27 06:00 [pubmed]
PHST- 2013/09/13 06:00 [medline]
PHST- 2014/04/05 00:00 [pmc-release]
AID - rstb.2012.0435 [pii]
AID - rstb20120435 [pii]
AID - 10.1098/rstb.2012.0435 [doi]
PST - epublish
SO  - Philos Trans R Soc Lond B Biol Sci. 2013 Feb 25;368(1615):20120435. doi: 
      10.1098/rstb.2012.0435. Print 2013.