PMID- 23441776
OWN - NLM
STAT- MEDLINE
DCOM- 20130813
LR  - 20221207
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 16
IP  - 1
DP  - 2013 Feb
TI  - Androgen receptor genetic variants in male patients with ankylosing spondylitis 
      in Taiwan.
PG  - 81-7
LID - 10.1111/1756-185X.12011 [doi]
AB  - AIM: Ankylosing spondylitis (AS) is a chronic rheumatic disorder with gender 
      differences. The aim of study was to investigate the association between 
      polymorphisms of the androgen receptor (AR) gene and the susceptibility to AS in 
      Taiwanese men of Han Chinese descent. METHODS: We conducted a case-control study 
      with 92 male AS patients and 108 healthy controls. Trinucleotide (CAG and GGC) 
      repeats and seven single nucleotide polymorphisms (SNPs) rs962458, rs6152, 
      rs1204038, rs5918757, rs2361634, rs6624304 and rs1337080 in the AR gene were 
      genotyped. RESULTS: We found that only one patient had polymorphic SNPs of the AR 
      gene. None of the genotyped SNPs in the AR gene, originally found in Caucasians, 
      was polymorphic in the Taiwanese men. Neither CAG nor GGC repeat lengths in the 
      AR gene had a significant relationship with human leukocyte antigen (HLA)-B27 
      positivity or disease severity in AS. CONCLUSION: There were no differences in 
      CAG and GGC lengths in the AR gene between AS and the controls. None of the 
      genotyped SNPs in AR gene are detected to be polymorphic in male Taiwanese, which 
      indicates that the effect of AR gene on AS may be ethnic-specific and may be 
      conserved in East Asians compared to Caucasian populations. Still, additional 
      studies using large sets of subjects deserve further attention, since our sample 
      size was small with limited statistical power and supporting evidence for 
      association between the AR gene and AS risk in the Japanese population exists.
CI  - (c) 2012 The Authors International Journal of Rheumatic Diseases (c) 2012 Asia 
      Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty 
      Ltd.
FAU - Yu, Shan-Fu
AU  - Yu SF
AD  - Division of Rheumatology, Allergy and Immunology, Department of Internal 
      Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang-Gung University College 
      of Medicine, Kaohsiung, Taiwan.
FAU - Hsu, Yi-Hsiang
AU  - Hsu YH
FAU - Cheng, Tien-Tsai
AU  - Cheng TT
FAU - Lai, Han-Ming
AU  - Lai HM
FAU - Chen, Chung-Jen
AU  - Chen CJ
FAU - Kang, Hong-Yo
AU  - Kang HY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121020
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Biomarkers)
RN  - 0 (Receptors, Androgen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Androgen/*genetics/metabolism
MH  - Spondylitis, Ankylosing/ethnology/*genetics/metabolism
MH  - Taiwan/ethnology
MH  - Trinucleotide Repeats
MH  - White People/genetics
MH  - Young Adult
EDAT- 2013/02/28 06:00
MHDA- 2013/08/14 06:00
CRDT- 2013/02/28 06:00
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2013/08/14 06:00 [medline]
AID - 10.1111/1756-185X.12011 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2013 Feb;16(1):81-7. doi: 10.1111/1756-185X.12011. Epub 2012 Oct 
      20.