PMID- 23442115
OWN - NLM
STAT- MEDLINE
DCOM- 20130816
LR  - 20160526
IS  - 1532-4117 (Electronic)
IS  - 1093-4529 (Linking)
VI  - 48
IP  - 6
DP  - 2013
TI  - Variability of bioaccessibility results using seventeen different methods on a 
      standard reference material, NIST 2710.
PG  - 641-55
LID - 10.1080/10934529.2013.731817 [doi]
AB  - Bioaccessibility is a measurement of a substance's solubility in the human 
      gastro-intestinal system, and is often used in the risk assessment of soils. The 
      present study was designed to determine the variability among laboratories using 
      different methods to measure the bioaccessibility of 24 inorganic contaminants in 
      one standardized soil sample, the standard reference material NIST 2710. Fourteen 
      laboratories used a total of 17 bioaccessibility extraction methods. The 
      variability between methods was assessed by calculating the reproducibility 
      relative standard deviations (RSDs), where reproducibility is the sum of 
      within-laboratory and between-laboratory variability. Whereas within-laboratory 
      repeatability was usually better than (<) 15% for most elements, reproducibility 
      RSDs were much higher, indicating more variability, although for many elements 
      they were comparable to typical uncertainties (e.g., 30% in commercial 
      laboratories). For five trace elements of interest, reproducibility RSDs were: 
      arsenic (As), 22-44%; cadmium (Cd), 11-41%; Cu, 15-30%; lead (Pb), 45-83%; and 
      Zn, 18-56%. Only one method variable, pH, was found to correlate significantly 
      with bioaccessibility for aluminum (Al), Cd, copper (Cu), manganese (Mn), Pb and 
      zinc (Zn) but other method variables could not be examined systematically because 
      of the study design. When bioaccessibility results were directly compared with 
      bioavailability results for As (swine and mouse) and Pb (swine), four methods 
      returned results within uncertainty ranges for both elements: two that were 
      defined as simpler (gastric phase only, limited chemicals) and two were more 
      complex (gastric + intestinal phases, with a mixture of chemicals).
FAU - Koch, Iris
AU  - Koch I
AD  - Environmental Sciences Group, Royal Military College of Canada, Kingston, 
      Ontario, Canada.
FAU - Reimer, Kenneth J
AU  - Reimer KJ
FAU - Bakker, Martine I
AU  - Bakker MI
FAU - Basta, Nicholas T
AU  - Basta NT
FAU - Cave, Mark R
AU  - Cave MR
FAU - Denys, Sebastien
AU  - Denys S
FAU - Dodd, Matt
AU  - Dodd M
FAU - Hale, Beverly A
AU  - Hale BA
FAU - Irwin, Rob
AU  - Irwin R
FAU - Lowney, Yvette W
AU  - Lowney YW
FAU - Moore, Margo M
AU  - Moore MM
FAU - Paquin, Viviane
AU  - Paquin V
FAU - Rasmussen, Pat E
AU  - Rasmussen PE
FAU - Repaso-Subang, Theresa
AU  - Repaso-Subang T
FAU - Stephenson, Gladys L
AU  - Stephenson GL
FAU - Siciliano, Steven D
AU  - Siciliano SD
FAU - Wragg, Joanna
AU  - Wragg J
FAU - Zagury, Gerald J
AU  - Zagury GJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Environ Sci Health A Tox Hazard Subst Environ Eng
JT  - Journal of environmental science and health. Part A, Toxic/hazardous substances & 
      environmental engineering
JID - 9812551
RN  - 0 (Soil Pollutants)
SB  - IM
MH  - Environmental Monitoring/*methods/*standards
MH  - Gastrointestinal Tract/metabolism
MH  - Humans
MH  - *Laboratories/standards
MH  - *Models, Biological
MH  - Reference Standards
MH  - Reproducibility of Results
MH  - *Soil Pollutants/analysis/pharmacokinetics
MH  - United States
MH  - United States Government Agencies
EDAT- 2013/02/28 06:00
MHDA- 2013/08/21 06:00
CRDT- 2013/02/28 06:00
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - 10.1080/10934529.2013.731817 [doi]
PST - ppublish
SO  - J Environ Sci Health A Tox Hazard Subst Environ Eng. 2013;48(6):641-55. doi: 
      10.1080/10934529.2013.731817.