PMID- 23442303
OWN - NLM
STAT- MEDLINE
DCOM- 20130904
LR  - 20130628
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 32
IP  - 4
DP  - 2013 Jul-Aug
TI  - Genetic changes with prognostic value in histologically benign meningiomas.
PG  - 311-7
LID - 10.5414/NP300580 [doi]
AB  - Meningiomas add up to 25% of intracranial tumors. Although the majority is 
      considered histologically benign, the prediction of their potential 
      aggressiveness is still unclear. We studied the histopathology and aberrations of 
      chromosomes 1p, 14, and 22 by FISH (fluorescence in situ hybridization) in 
      histologically benign meningiomas of 70 patients for the purpose of defining the 
      prognostic value of these alterations in tumoral progression and the risk of 
      recurrence. According to the WHO histopathological criteria, the study set 
      comprised 53 benign, 11 atypical, and 6 anaplastic meningiomas. In benign 
      meningiomas, 25% of the cases displayed a normal karyotype, isolated monosomy 22 
      (36%), monosomy 22 + 1p deletion (14%), 1p deletion (10%), monosomy 22 + 14q 
      deletion (5%), monosomy 22 + 1p deletion + 14q deletion (5%), or other 
      alterations (5%). Grade II meningiomas presented losses in chromosome 14 in most 
      of the cases (67%), and Grade III meningiomas showed alterations in chromosome 14 
      in all patients. We observed an overall relapse rate of 31%: recurrence was 
      observed in 19% of Grade I meningiomas, 64% of Grade II, and 83% of Grade III. 9 
      out of 10 recurrent cases revealed abnormalities in chromosomes 1 and 14, which 
      was a notably higher incidence compared to the series of tumors without relapse. 
      Thus, benign meningiomas with cytogenetic alterations in chromosomes 1p and 14 
      may be more closely related to atypical meningiomas than benign meningiomas 
      without these alterations, especially in terms of recurrence risk.
FAU - Barbera, Sandra
AU  - Barbera S
AD  - Department of Pathology, University of Valencia, Valencia, Spain.
FAU - San Miguel, Teresa
AU  - San Miguel T
FAU - Gil-Benso, Rosario
AU  - Gil-Benso R
FAU - Munoz-Hidalgo, Lisandra
AU  - Munoz-Hidalgo L
FAU - Roldan, Pedro
AU  - Roldan P
FAU - Gonzalez-Darder, Jose
AU  - Gonzalez-Darder J
FAU - Cerda-Nicolas, Miguel
AU  - Cerda-Nicolas M
FAU - Lopez-Gines, Concha
AU  - Lopez-Gines C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 22/genetics
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Meningeal Neoplasms/*genetics/pathology
MH  - Meningioma/*genetics/pathology
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Recurrence, Local/*genetics/pathology
MH  - Prognosis
MH  - Tissue Array Analysis
MH  - Young Adult
EDAT- 2013/02/28 06:00
MHDA- 2013/09/05 06:00
CRDT- 2013/02/28 06:00
PHST- 2013/06/28 00:00 [accepted]
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2013/09/05 06:00 [medline]
AID - 10442 [pii]
AID - 10.5414/NP300580 [doi]
PST - ppublish
SO  - Clin Neuropathol. 2013 Jul-Aug;32(4):311-7. doi: 10.5414/NP300580.