PMID- 23442713
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20191210
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 134
IP  - 4
DP  - 2012 Oct 15
TI  - Systematic optimisation of coupled microwave-assisted extraction-solid phase 
      extraction for the determination of pesticides in infant milk formula via 
      LC-MS/MS.
PG  - 2473-80
LID - 10.1016/j.foodchem.2012.04.076 [doi]
AB  - An extraction method consisting of both microwave-assisted extraction (MAE) and 
      solid phase extraction (SPE) was developed to extract pesticides of different 
      polarities in infant milk formula. An experimental central face composite design 
      was established to evaluate the effects of several MAE variables simultaneously 
      such as temperature and pH of extractant. With Derringer desirability function, 
      all pesticides were optimally extracted at 102  degrees C within 20 min with 4.56 mL of 
      extractant consisting of 0.1% of water in methanol at pH 12. Extraction 
      efficiency was subsequently analysed with LC-MS/MS. The extraction recoveries 
      ranging from 72% to 111% were obtained for all pesticides at fortification level 
      of 5-100 mug kg(-1) with relative standard deviations (RSDs) of less than 8%. 
      Compared with Soxhlet/SPE, the MAE/SPE method utilised less solvent and higher 
      recoveries were achieved with a shorter extraction time.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Fang, Guihua
AU  - Fang G
AD  - Department of Chemistry, National University of Singapore, Singapore, Republic of 
      Singapore.
FAU - Lau, Hiu Fung
AU  - Lau HF
FAU - Law, Wai Siang
AU  - Law WS
FAU - Li, Sam Fong Yau
AU  - Li SF
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120421
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Pesticides)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Chromatography, High Pressure Liquid/methods
MH  - Infant Formula/*chemistry
MH  - Microwaves
MH  - Pesticides/*analysis/*isolation & purification
MH  - Solid Phase Extraction/instrumentation/*methods
MH  - Tandem Mass Spectrometry/methods
EDAT- 2013/02/28 06:00
MHDA- 2013/08/24 06:00
CRDT- 2013/02/28 06:00
PHST- 2011/02/09 00:00 [received]
PHST- 2011/11/03 00:00 [revised]
PHST- 2012/04/14 00:00 [accepted]
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - S0308-8146(12)00739-X [pii]
AID - 10.1016/j.foodchem.2012.04.076 [doi]
PST - ppublish
SO  - Food Chem. 2012 Oct 15;134(4):2473-80. doi: 10.1016/j.foodchem.2012.04.076. Epub 
      2012 Apr 21.