PMID- 23443026
OWN - NLM
STAT- MEDLINE
DCOM- 20140501
LR  - 20211021
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Print)
IS  - 1018-4813 (Linking)
VI  - 21
IP  - 10
DP  - 2013 Oct
TI  - HLA-DQB1*02 and DQB1*06:03P are associated with peanut allergy.
PG  - 1181-4
LID - 10.1038/ejhg.2013.13 [doi]
AB  - Peanut allergy (PA) is a common and serious food allergy and its prevalence has 
      increased in the past decade. Although there is strong evidence of inheritance, 
      the genetic causes of this disease are not well understood. Previously, a 
      large-scale genome-wide association study described an association between human 
      leukocyte antigen (HLA)-DQB1 and asthma; the aim of this study was to evaluate 
      the association between HLA-DQB1 and PA. Genotypic and allelic profiles were 
      established for 311 Caucasian members of a well-described Canadian group of 
      children with PA and 226 Caucasian controls. Firth's logistic regression analyses 
      showed associations between HLA-DQB1 alleles and PA for DQB1*02 (P=1.1 x 10(-8), 
      odds ratio (OR)=0.09 (CI=0.03-0.23)) and DQB1*06:03P alleles (P=2.1 x 10(-2), 
      OR=2.82 (CI=1.48-5.45)). This study of HLA in PA demonstrates specific 
      association between two allelic groups of the HLA-DQB1 gene (DQB1*02 and 
      DQB1*06:03P) and PA, highlighting its possible role in the development of this 
      disease.
FAU - Madore, Anne-Marie
AU  - Madore AM
AD  - Departement des Sciences Fondamentales, Universite du Quebec a Chicoutimi, 
      Saguenay, Quebec, Canada.
FAU - Vaillancourt, Vanessa T
AU  - Vaillancourt VT
FAU - Asai, Yuka
AU  - Asai Y
FAU - Alizadehfar, Reza
AU  - Alizadehfar R
FAU - Ben-Shoshan, Moshe
AU  - Ben-Shoshan M
FAU - Michel, Deborah L
AU  - Michel DL
FAU - Kozyrskyj, Anita L
AU  - Kozyrskyj AL
FAU - Becker, Allan
AU  - Becker A
FAU - Chan-Yeung, Moira
AU  - Chan-Yeung M
FAU - Clarke, Ann E
AU  - Clarke AE
FAU - Hull, Peter
AU  - Hull P
FAU - Daley, Denise
AU  - Daley D
FAU - Sandford, Andrew J
AU  - Sandford AJ
FAU - Laprise, Catherine
AU  - Laprise C
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130227
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Child, Preschool
MH  - Female
MH  - Genetic Association Studies
MH  - HLA-DQ beta-Chains/*genetics
MH  - Humans
MH  - Male
MH  - Peanut Hypersensitivity/*genetics
PMC - PMC3778350
EDAT- 2013/02/28 06:00
MHDA- 2014/05/03 06:00
PMCR- 2014/10/01
CRDT- 2013/02/28 06:00
PHST- 2012/07/02 00:00 [received]
PHST- 2013/01/14 00:00 [revised]
PHST- 2013/01/17 00:00 [accepted]
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - ejhg201313 [pii]
AID - 10.1038/ejhg.2013.13 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2013 Oct;21(10):1181-4. doi: 10.1038/ejhg.2013.13. Epub 2013 Feb 
      27.