PMID- 23443053
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130321
LR  - 20211021
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 5
IP  - 1
DP  - 2013 Feb 26
TI  - Noninvasive assessment of the carotid and cerebrovascular atherosclerotic plaques 
      by multidetector CT in type-2 diabetes mellitus patients with transient ischemic 
      attack or stroke.
PG  - 9
LID - 10.1186/1758-5996-5-9 [doi]
AB  - BACKGROUND: The cerebrovasuclar artery disease as a common complication of type-2 
      diabetes mellitus (T2DM) caused huge economic burden and lives threatening to 
      patients. We evaluated the prevalence and morphology of carotid and 
      cerebrovascular atherosclerotic plaques in T2DM patients with transient ischemic 
      attack (TIA) or stroke using multidetector CT (MDCT). METHODS: 64-MDCT and 
      dual-source CT (DSCT) angiographies were performed in 195 T2DM patients with TIA 
      or stroke (mean age 65.7+/-12.8 years; 118 men) between January 2009 to August 
      2011. During the process, plaque type, its distribution, extensive and 
      obstructive natures were determined for each segment derived from the patients. 
      RESULTS: Atherosclerotic plaques were detected in 183 (93.8%) patients. A total 
      of 1056 segments with plaque were identified, of which 450 (42.6%) were 
      non-calcified, 192 (18.2%) were mixed and 414 (39.2%) calcified ones. Among them, 
      562 (53.2%) resulted in mild stenosis, 291 (27.6%) moderate stenosis, 170 (16.1%) 
      severe stenosis and 33 (3.1%) occlusion. Non-calcified plaques contributed 91.8% 
      to non-obstructive lumen narrowing, while mixed and calcified plaques contributed 
      89.0% and 65.0% respectively. CONCLUSIONS: MDCT angiography detected a high 
      prevalence of plaques in T2DM patients with TIA or stroke. A relatively high 
      proportion of plaques were non-calcified, as well as with non-obstructive 
      stenosis. MDCT angiography might further enhance the detection and management of 
      carotid and cerebrovascular atherosclerosis in T2DM patients with TIA and stroke.
FAU - He, Ci
AU  - He C
AD  - Department of Radiology, Chengdu Military General Hospital, Chengdu, Peoples' 
      Republic of China. hecicd@163.com.
FAU - Gu, Ming
AU  - Gu M
FAU - Jiang, Rui
AU  - Jiang R
FAU - Li, Jian-Hao
AU  - Li JH
LA  - eng
PT  - Journal Article
DEP - 20130226
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC3598273
EDAT- 2013/02/28 06:00
MHDA- 2013/02/28 06:01
PMCR- 2013/02/26
CRDT- 2013/02/28 06:00
PHST- 2012/07/10 00:00 [received]
PHST- 2013/02/20 00:00 [accepted]
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2013/02/28 06:01 [medline]
PHST- 2013/02/26 00:00 [pmc-release]
AID - 1758-5996-5-9 [pii]
AID - 10.1186/1758-5996-5-9 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2013 Feb 26;5(1):9. doi: 10.1186/1758-5996-5-9.