PMID- 23443175
OWN - NLM
STAT- MEDLINE
DCOM- 20130628
LR  - 20211021
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 33
IP  - 5
DP  - 2013 May
TI  - Post ischemia intermittent hypoxia induces hippocampal neurogenesis and synaptic 
      alterations and alleviates long-term memory impairment.
PG  - 764-73
LID - 10.1038/jcbfm.2013.15 [doi]
AB  - Adult hippocampal neurogenesis is important for learning and memory, especially 
      after a brain injury such as ischemia. Newborn hippocampal neurons contribute to 
      memory performance by establishing functional synapses with target cells. This 
      study demonstrated that the maturation of hippocampal neurons is enhanced by 
      postischemia intermittent hypoxia (IH) intervention. The effects of IH 
      intervention in cultured neurons were mediated by increased synaptogenesis, which 
      was primarily regulated by brain-derived neurotrophic factor (BDNF)/PI3K/AKT. 
      Hippocampal neo-neurons expressed BDNF and exhibited enhanced presynaptic 
      function as indicated by increases in the pSynapsin expression, synaptophysin 
      intensity, and postsynapse density following IH intervention after ischemia. 
      Postischemia IH-induced hippocampal neo-neurons were affected by presynaptic 
      activity, which reflected the dynamic plasticity of the glutamatergic receptors. 
      These alterations were also associated with the alleviation of ischemia-induced 
      long-term memory impairment. Our results suggest that postischemia IH 
      intervention rescued ischemia-induced spatial learning and memory impairment by 
      inducing hippocampal neurogenesis and functional synaptogenesis via BDNF 
      expression.
FAU - Tsai, Yi-Wei
AU  - Tsai YW
AD  - Department and Institute of Physical Therapy and Assistive Technology, National 
      Yang-Ming University, Taipei, Taiwan.
FAU - Yang, Yea-Ru
AU  - Yang YR
FAU - Sun, Synthia H
AU  - Sun SH
FAU - Liang, Keng-Chen
AU  - Liang KC
FAU - Wang, Ray-Yau
AU  - Wang RY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130227
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Hypoxia
MH  - Cells, Cultured
MH  - Hippocampus/*cytology
MH  - Male
MH  - Memory Disorders/*metabolism
MH  - *Memory, Long-Term
MH  - *Neurogenesis
MH  - Neurons/*cytology/metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synapses/metabolism
PMC - PMC3652689
EDAT- 2013/02/28 06:00
MHDA- 2013/07/03 06:00
PMCR- 2014/05/01
CRDT- 2013/02/28 06:00
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - jcbfm201315 [pii]
AID - 10.1038/jcbfm.2013.15 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2013 May;33(5):764-73. doi: 10.1038/jcbfm.2013.15. Epub 
      2013 Feb 27.