PMID- 23443554
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20211021
IS  - 2041-1723 (Electronic)
IS  - 2041-1723 (Linking)
VI  - 4
DP  - 2013
TI  - Haematopoietic cells produce BDNF and regulate appetite upon migration to the 
      hypothalamus.
PG  - 1526
LID - 10.1038/ncomms2536 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) suppresses food intake by acting on 
      neurons in the hypothalamus. Here we show that BDNF-producing haematopoietic 
      cells control appetite and energy balance by migrating to the hypothalamic 
      paraventricular nucleus. These haematopoietic-derived paraventricular nucleus 
      cells produce microglial markers and make direct contacts with neurons in 
      response to feeding status. Mice with congenital BDNF deficiency, specifically in 
      haematopoietic cells, develop hyperphagia, obesity and insulin resistance. These 
      abnormalities are ameliorated by bone marrow transplantation with wild-type bone 
      marrow cells. Furthermore, when injected into the third ventricle, wild-type bone 
      marrow mononuclear cells home to the paraventricular nucleus and reverse the 
      hyperphagia of BDNF-deficient mice. Our results suggest a novel mechanism of 
      feeding control based on the production of BDNF by haematopoietic cells and 
      highlight a potential new therapeutic route for the treatment of obesity.
FAU - Urabe, Hiroshi
AU  - Urabe H
AD  - Department of Molecular Genetics in Medicine, Shiga University of Medical 
      Science, Otsu, Shiga 520-2192, Japan.
FAU - Kojima, Hideto
AU  - Kojima H
FAU - Chan, Lawrence
AU  - Chan L
FAU - Terashima, Tomoya
AU  - Terashima T
FAU - Ogawa, Nobuhiro
AU  - Ogawa N
FAU - Katagi, Miwako
AU  - Katagi M
FAU - Fujino, Kazunori
AU  - Fujino K
FAU - Kumagai, Asako
AU  - Kumagai A
FAU - Kawai, Hiromichi
AU  - Kawai H
FAU - Asakawa, Akihiro
AU  - Asakawa A
FAU - Inui, Akio
AU  - Inui A
FAU - Yasuda, Hitoshi
AU  - Yasuda H
FAU - Eguchi, Yutaka
AU  - Eguchi Y
FAU - Oka, Kazuhiro
AU  - Oka K
FAU - Maegawa, Hiroshi
AU  - Maegawa H
FAU - Kashiwagi, Atsunori
AU  - Kashiwagi A
FAU - Kimura, Hiroshi
AU  - Kimura H
LA  - eng
GR  - P30 DK079638/DK/NIDDK NIH HHS/United States
GR  - R01 HL051586/HL/NHLBI NIH HHS/United States
GR  - P30 DK79638/DK/NIDDK NIH HHS/United States
GR  - HL-51586/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nat Commun
JT  - Nature communications
JID - 101528555
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - *Appetite/drug effects
MH  - Body Weight/drug effects
MH  - Bone Marrow Cells/drug effects/metabolism/pathology
MH  - Bone Marrow Transplantation
MH  - Brain-Derived Neurotrophic Factor/administration & 
      dosage/deficiency/metabolism/pharmacology
MH  - *Cell Movement/drug effects
MH  - Drinking Behavior/drug effects
MH  - Fasting/metabolism
MH  - Feeding Behavior/drug effects
MH  - Gene Deletion
MH  - Hematopoietic Stem Cells/drug effects/*metabolism/*pathology
MH  - Hyperphagia/complications/pathology/physiopathology
MH  - Hypothalamus/drug effects/*metabolism/pathology/ultrastructure
MH  - Injections, Intraventricular
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Microglia/drug effects/metabolism/pathology
MH  - Obesity/complications/pathology/physiopathology
MH  - Organ Specificity/drug effects
MH  - Paraventricular Hypothalamic Nucleus/drug 
      effects/metabolism/pathology/ultrastructure
PMC - PMC3640364
MID - NIHMS453571
EDAT- 2013/02/28 06:00
MHDA- 2013/06/21 06:00
PMCR- 2014/02/26
CRDT- 2013/02/28 06:00
PHST- 2012/12/27 00:00 [received]
PHST- 2013/01/23 00:00 [accepted]
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
PHST- 2014/02/26 00:00 [pmc-release]
AID - ncomms2536 [pii]
AID - 10.1038/ncomms2536 [doi]
PST - ppublish
SO  - Nat Commun. 2013;4:1526. doi: 10.1038/ncomms2536.