PMID- 23444117
OWN - NLM
STAT- MEDLINE
DCOM- 20130912
LR  - 20160303
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 133
IP  - 6
DP  - 2013 Sep 15
TI  - Dietary total antioxidant capacity and colorectal cancer: a large case-control 
      study in Italy.
PG  - 1447-51
LID - 10.1002/ijc.28133 [doi]
AB  - A favorable role of fruit and vegetables on colorectal cancer risk has been 
      related to the antioxidant properties of their components. We used data from an 
      Italian case-control study including 1,953 patients with incident, histologically 
      confirmed colorectal cancer (1,225 colon and 728 rectal cancers). Controls were 
      4,154 patients admitted to hospital for acute, non-neoplastic conditions. A 
      reproducible and valid food frequency questionnaire was used to assess subjects' 
      usual diet. Total antioxidant capacity (TAC) was measured using Italian food 
      composition tables in terms of ferric reducing-antioxidant power (FRAP), Trolox 
      equivalent antioxidant capacity (TEAC) and total radical-trapping antioxidant 
      parameter (TRAP). We estimated the odds ratios (ORs) and the corresponding 95% 
      confidence intervals (CIs) through multiple logistic regression models, including 
      terms for potential confounding factors, and energy intake. TAC was inversely 
      related with colorectal cancer risk: the OR for the highest versus the lowest 
      quintile was 0.68 (95% CI, 0.57-0.82) for FRAP, 0.69 (95% CI, 0.57-0.83) for TEAC 
      and 0.69 (95% CI, 0.57-0.83) for TRAP. Corresponding values, excluding TAC 
      deriving from coffee, were 0.75 (95% CI, 0.61-0.93) for FRAP, 0.76 (95% CI, 
      0.61-0.93) for TEAC and 0.71 (95% CI, 0.57-0.89) for TRAP. The inverse 
      association was apparently-though not significantly-stronger for rectal than for 
      colon cancer. This is the first case-control study indicating consistent inverse 
      relations between dietary TAC and colorectal cancer risk.
CI  - Copyright (c) 2013 UICC.
FAU - La Vecchia, Carlo
AU  - La Vecchia C
AD  - Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario 
      Negri-IRCCS, Milan, Italy.
FAU - Decarli, Adriano
AU  - Decarli A
FAU - Serafini, Mauro
AU  - Serafini M
FAU - Parpinel, Maria
AU  - Parpinel M
FAU - Bellocco, Rino
AU  - Bellocco R
FAU - Galeone, Carlotta
AU  - Galeone C
FAU - Bosetti, Cristina
AU  - Bosetti C
FAU - Zucchetto, Antonella
AU  - Zucchetto A
FAU - Polesel, Jerry
AU  - Polesel J
FAU - Lagiou, Pagona
AU  - Lagiou P
FAU - Negri, Eva
AU  - Negri E
FAU - Rossi, Marta
AU  - Rossi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130404
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Antioxidants)
SB  - IM
MH  - Antioxidants/*administration & dosage
MH  - Case-Control Studies
MH  - Colorectal Neoplasms/*prevention & control
MH  - *Diet
MH  - Fruit
MH  - Humans
MH  - Italy
MH  - Logistic Models
MH  - Odds Ratio
MH  - Risk
MH  - Vegetables
OTO - NOTNLM
OT  - colorectal cancer
OT  - diet
OT  - non enzymatic antioxidant capacity
OT  - risk
OT  - total antioxidant capacity
EDAT- 2013/02/28 06:00
MHDA- 2013/09/13 06:00
CRDT- 2013/02/28 06:00
PHST- 2012/08/22 00:00 [received]
PHST- 2013/02/07 00:00 [accepted]
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2013/09/13 06:00 [medline]
AID - 10.1002/ijc.28133 [doi]
PST - ppublish
SO  - Int J Cancer. 2013 Sep 15;133(6):1447-51. doi: 10.1002/ijc.28133. Epub 2013 Apr 
      4.