PMID- 23444210
OWN - NLM
STAT- MEDLINE
DCOM- 20140425
LR  - 20220331
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 41
IP  - 10
DP  - 2013 Oct
TI  - Comparison of fluorescence in situ hybridization, NMP22 bladderchek, and urinary 
      liquid-based cytology in the detection of bladder urothelial carcinoma.
PG  - 852-7
LID - 10.1002/dc.22969 [doi]
AB  - The aim of this study is to evaluate the diagnostic values of the fluorescence in 
      situ hybridization (FISH), NMP22 BladderChek, and liquid-based cytology (LBC) in 
      the detection of bladder urothelial carcinoma (UC). Consecutive voided urine 
      samples were collected from 138 in-house patients with a variety of urologic 
      conditions and 37 healthy individuals as negative controls. FISH, NMP22 
      BladderChek, and LBC were performed on the specimens. All three tests were 
      evaluated independently in a blinded fashion. In all, 104 out of the 175 patients 
      enrolled in this study had histologically proven UC. LBC, FISH, and NMP22 
      BladderChek were successfully performed on 175, 149, and 119 cases, respectively. 
      The three tests revealed overall sensitivities of 73.1%, 86.5%, and 67.6%, 
      respectively. FISH was more sensitive than LBC (P=0.022) and NMP22 BladderChek 
      (P=0.004). Combination of all the tests yielded a superior sensitivity of 96.7% 
      compared with LBC (P<0.001), NMP22 BladderChek (P<0.001), and FISH (P=0.016), 
      with the specificity only decreased slightly. Sensitivities of the three tests 
      enhanced significantly with increasing UC grade (P<0.05). The positive rates of 
      FISH and NMP22 BladderChek in equivocal cytologic diagnoses were 85.7% and 61.9% 
      in UC, and 37.5% and 50.0% in non-UC (FISH: P=0.021; NMP22 BladderChek: P=0.683). 
      FISH was more sensitive than LBC and NMP22 BladderChek. FISH had the ability to 
      clarify equivocal cytologic diagnoses. Combination of all three tests showed an 
      improvement in the sensitivity compared to any single test alone in detecting UC 
      with the specificity slightly decreased.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Li, Hong-xia
AU  - Li HX
AD  - Department of Pathology, General Hospital of Chinese PLA Beijing Military Command 
      Area, Beijing, People's Republic of China.
FAU - Wang, Ming-rong
AU  - Wang MR
FAU - Zhao, Huan
AU  - Zhao H
FAU - Cao, Jian
AU  - Cao J
FAU - Li, Chang-ling
AU  - Li CL
FAU - Pan, Qin-Jing
AU  - Pan QJ
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20130227
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma/*diagnosis/pathology
MH  - Case-Control Studies
MH  - Cytodiagnosis/*methods
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Male
MH  - Middle Aged
MH  - Sensitivity and Specificity
MH  - Urinary Bladder Neoplasms/*diagnosis/pathology
OTO - NOTNLM
OT  - FISH
OT  - NMP22 BladderChek
OT  - liquid-based Cytology
OT  - urothelial carcinoma
EDAT- 2013/02/28 06:00
MHDA- 2014/04/26 06:00
CRDT- 2013/02/28 06:00
PHST- 2012/05/04 00:00 [received]
PHST- 2013/01/01 00:00 [accepted]
PHST- 2013/02/28 06:00 [entrez]
PHST- 2013/02/28 06:00 [pubmed]
PHST- 2014/04/26 06:00 [medline]
AID - 10.1002/dc.22969 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2013 Oct;41(10):852-7. doi: 10.1002/dc.22969. Epub 2013 Feb 27.