PMID- 23444983
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20211021
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Print)
IS  - 0300-0664 (Linking)
VI  - 79
IP  - 4
DP  - 2013 Oct
TI  - Favourable metabolic effects of a eucaloric lower-carbohydrate diet in women with 
      PCOS.
PG  - 550-7
LID - 10.1111/cen.12175 [doi]
AB  - OBJECTIVE: Diet-induced reduction in circulating insulin may be an attractive 
      nonpharmacological treatment for women with polycystic ovary syndrome (PCOS) 
      among whom elevated insulin may exacerbate symptoms by stimulating testosterone 
      synthesis. This study was designed to determine whether a modest reduction in 
      dietary carbohydrate (CHO) content affects beta-cell responsiveness, serum 
      testosterone concentration and insulin sensitivity in women with PCOS. DESIGN: In 
      a crossover design, two diets ('Standard,' STD, 55:18:27% energy from 
      carbohydrate/protein/fat; lower-carbohydrate, 41:19:40) were provided for 8 weeks 
      in random order with a 4-week washout between. PATIENTS: Thirty women with PCOS. 
      MEASUREMENTS: beta-cell responsiveness assessed as the C-peptide response to glucose 
      during a liquid meal test; insulin sensitivity from insulin and glucose values 
      throughout the test; insulin resistance (HOMA-IR); and total testosterone by 
      immunoassay. RESULTS: Paired t-test indicated that the lower-CHO diet induced 
      significant decreases in basal beta-cell response (PhiB), fasting insulin, fasting 
      glucose, HOMA-IR, total testosterone and all cholesterol measures, and 
      significant increases in insulin sensitivity and dynamic ('first-phase') beta-cell 
      response. The STD diet induced a decrease in HDL-C and an increase in the total 
      cholesterol-to-HDL-C ratio. Across all data combined, the change in testosterone 
      was positively associated with the changes in fasting insulin, PhiB and insulin 
      AUC (P < 0.05). CONCLUSIONS: In women with PCOS, modest reduction in dietary CHO 
      in the context of a weight-maintaining diet has numerous beneficial effects on 
      the metabolic profile that may lead to a decrease in circulating testosterone.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Gower, Barbara A
AU  - Gower BA
AD  - Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 
      University Blvd., Birmingham, AL 35294, USA. bgower@uab.edu
FAU - Chandler-Laney, Paula C
AU  - Chandler-Laney PC
FAU - Ovalle, Fernando
AU  - Ovalle F
FAU - Goree, Laura Lee
AU  - Goree LL
FAU - Azziz, Ricardo
AU  - Azziz R
FAU - Desmond, Renee A
AU  - Desmond RA
FAU - Granger, Wesley M
AU  - Granger WM
FAU - Goss, Amy M
AU  - Goss AM
FAU - Bates, G Wright
AU  - Bates GW
LA  - eng
GR  - P30 DK079626/DK/NIDDK NIH HHS/United States
GR  - T32 DK062710/DK/NIDDK NIH HHS/United States
GR  - P60 DK079626/DK/NIDDK NIH HHS/United States
GR  - P30 DK056336/DK/NIDDK NIH HHS/United States
GR  - R01 HD054960/HD/NICHD NIH HHS/United States
GR  - UL1 RR025777/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20130520
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Fasting/blood
MH  - Female
MH  - Humans
MH  - Insulin/blood/*metabolism
MH  - Insulin Resistance
MH  - Insulin-Secreting Cells/*metabolism
MH  - Lipids/blood
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Polycystic Ovary Syndrome/blood/*diet therapy
MH  - Testosterone/blood
MH  - Young Adult
PMC - PMC4111472
MID - NIHMS597201
COIS- Conflict of interest Nothing to declare.
EDAT- 2013/03/01 06:00
MHDA- 2014/04/05 06:00
PMCR- 2014/07/25
CRDT- 2013/03/01 06:00
PHST- 2012/12/06 00:00 [received]
PHST- 2012/12/20 00:00 [revised]
PHST- 2013/02/13 00:00 [revised]
PHST- 2013/02/17 00:00 [accepted]
PHST- 2013/03/01 06:00 [entrez]
PHST- 2013/03/01 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
PHST- 2014/07/25 00:00 [pmc-release]
AID - 10.1111/cen.12175 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2013 Oct;79(4):550-7. doi: 10.1111/cen.12175. Epub 2013 
      May 20.