PMID- 23445834
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130319
LR  - 20220129
IS  - 2001-1326 (Print)
IS  - 2001-1326 (Electronic)
IS  - 2001-1326 (Linking)
VI  - 2
IP  - 1
DP  - 2013 Feb 27
TI  - Establishing a Southern Swedish Malignant Melanoma OMICS and biobank clinical 
      capability.
PG  - 7
LID - 10.1186/2001-1326-2-7 [doi]
AB  - BACKGROUND: The objectives and goals of the Southern Swedish Malignant Melanoma 
      (SSMM) are to develop, build and utilize cutting edge biobanks and OMICS 
      platforms to better understand disease pathology and drug mechanisms. The SSMM 
      research team is a truly cross-functional group with members from oncology, 
      surgery, bioinformatics, proteomics, and genomics initiatives. Within the 
      research team there are members who daily diagnose patients with suspect 
      melanomas, do follow-ups on malignant melanoma patients and remove primary or 
      metastatic lesions by surgery. This inter-disciplinary clinical patient care 
      ensures a competence build as well as a best practice procedure where the patient 
      benefits. METHODS: Clinical materials from patients before, during and after 
      treatments with clinical end points are being collected. Tissue samples as well 
      as bio-fluid samples such as blood fractions, plasma, serum and whole blood will 
      be archived in 384-high density sample tube formats. Standardized approaches for 
      patient selections, patient sampling, sample-processing and analysis platforms 
      with dedicated protein assays and genomics platforms that will hold value for the 
      research community are used. The patient biobank archives are fully automated 
      with novel ultralow temperature biobank storage units and used as clinical 
      resources. RESULTS: An IT-infrastructure using a laboratory information 
      management system (LIMS) has been established, that is the key interface for the 
      research teams in order to share and explore data generated within the project. 
      The cross-site data repository in Lund forms the basis for sample processing, 
      together with biological samples in southern Sweden, including blood fractions 
      and tumor tissues. Clinical registries are associated with the biobank materials, 
      including pathology reports on disease diagnosis on the malignant melanoma (MM) 
      patients. CONCLUSIONS: We provide data on the developments of protein profiling 
      and targeted protein assays on isolated melanoma tumors, as well as reference 
      blood standards that is used by the team members in the respective laboratories. 
      These pilot data show biobank access and feasibility of performing quantitative 
      proteomics in MM biobank repositories collected in southern Sweden. The 
      scientific outcomes further strengthen the build of healthcare benefit in the 
      complex challenges of malignant melanoma pathophysiology that is addressed by the 
      novel personalized medicines entering the market.
FAU - Welinder, Charlotte
AU  - Welinder C
AD  - Clinical Protein Science & Imaging, Biomedical Center, Dept, of Measurement 
      Technology and Industrial Electrical Engineering, Lund University, BMC C13, Lund 
      221 84, Sweden. Gyorgy.Marko-Varga@elmat.lth.se.
FAU - Jonsson, Goran
AU  - Jonsson G
FAU - Ingvar, Christian
AU  - Ingvar C
FAU - Lundgren, Lotta
AU  - Lundgren L
FAU - Olsson, Hakan
AU  - Olsson H
FAU - Breslin, Thomas
AU  - Breslin T
FAU - Vegvari, Akos
AU  - Vegvari A
FAU - Laurell, Thomas
AU  - Laurell T
FAU - Rezeli, Melinda
AU  - Rezeli M
FAU - Jansson, Bo
AU  - Jansson B
FAU - Baldetorp, Bo
AU  - Baldetorp B
FAU - Marko-Varga, Gyorgy
AU  - Marko-Varga G
LA  - eng
GR  - 294576/ERC_/European Research Council/International
PT  - Journal Article
DEP - 20130227
PL  - United States
TA  - Clin Transl Med
JT  - Clinical and translational medicine
JID - 101597971
PMC - PMC3599425
EDAT- 2013/03/01 06:00
MHDA- 2013/03/01 06:01
PMCR- 2013/02/27
CRDT- 2013/03/01 06:00
PHST- 2012/11/12 00:00 [received]
PHST- 2013/02/15 00:00 [accepted]
PHST- 2013/03/01 06:00 [entrez]
PHST- 2013/03/01 06:00 [pubmed]
PHST- 2013/03/01 06:01 [medline]
PHST- 2013/02/27 00:00 [pmc-release]
AID - 2001-1326-2-7 [pii]
AID - 10.1186/2001-1326-2-7 [doi]
PST - epublish
SO  - Clin Transl Med. 2013 Feb 27;2(1):7. doi: 10.1186/2001-1326-2-7.