PMID- 23446661
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130301
LR  - 20211021
IS  - 2044-4052 (Electronic)
IS  - 2044-4052 (Linking)
VI  - 2
IP  - 9
DP  - 2012 Sep 17
TI  - Vascular and metabolic effects of adrenaline in adipose tissue in type 2 
      diabetes.
PG  - e46
LID - 10.1038/nutd.2012.19 [doi]
AB  - OBJECTIVE: The aim was to investigate adipose tissue vascular and metabolic 
      effects of an adrenaline infusion in vivo in subjects with and without type 2 
      diabetes mellitus (T2DM). DESIGN: Clinical intervention study with 1-h 
      intravenous adrenaline infusion. SUBJECTS: Eight male overweight T2DM subjects 
      and eight male weight-matched, non-T2DM subjects were studied before, during and 
      after an 1-h intravenous adrenaline infusion. Adipose tissue blood flow (ATBF) 
      was determined by (133)Xenon wash-out technique, and microvascular volume in the 
      adipose tissue was studied by contrast-enhanced ultrasound imaging. Adipose 
      tissue fluxes of glycerol, non-esterified fatty acids (NEFA), triacylglycerol and 
      glucose were measured by Fick's principle after catherisation of a radial artery 
      and a vein draining the abdominal, subcutaneous adipose tissue. RESULTS: ATBF 
      increased similarly in both groups during the adrenaline infusion. One hour post 
      adrenaline, ATBF was still increased in overweight T2DM subjects. Adrenaline 
      increased microvascular volume in non-T2DM subjects while this response was 
      impaired in overweight T2DM subjects. Adrenaline-induced increase in lipolysis 
      was similar in both groups, but NEFA output from adipose tissue was delayed in 
      overweight T2DM subjects. Glucose uptake in adipose tissue increased in non-T2DM 
      subjects during adrenaline infusion but was unchanged in overweight T2DM 
      subjects. This results in a delayed excess release of NEFA from the adipose 
      tissue in overweight T2DM subjects after cessation of the adrenaline infusion. 
      CONCLUSION: Capillaries in the adipose tissue are recruited by adrenaline in 
      non-T2DM subjects; however, this response is impaired in overweight T2DM 
      subjects. NEFA, released in adipose tissue during adrenaline stimulation, is 
      insufficiently re-esterified in situ in overweight T2DM subjects, probably owing 
      to increased ATBF after adrenaline infusion and inability to increase adipose 
      tissue glucose uptake.
FAU - Tobin, L
AU  - Tobin L
AD  - Department of Clinical Physiology and Nuclearmedicine, Bispebjerg Hospital, 
      University of Copenhagen, Copenhagen NV, Denmark.
FAU - Simonsen, L
AU  - Simonsen L
FAU - Galbo, H
AU  - Galbo H
FAU - Bulow, J
AU  - Bulow J
LA  - eng
PT  - Journal Article
DEP - 20120917
PL  - England
TA  - Nutr Diabetes
JT  - Nutrition & diabetes
JID - 101566341
PMC - PMC3461355
EDAT- 2013/03/01 06:00
MHDA- 2013/03/01 06:01
PMCR- 2012/09/01
CRDT- 2013/03/01 06:00
PHST- 2013/03/01 06:00 [entrez]
PHST- 2013/03/01 06:00 [pubmed]
PHST- 2013/03/01 06:01 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - nutd201219 [pii]
AID - 10.1038/nutd.2012.19 [doi]
PST - epublish
SO  - Nutr Diabetes. 2012 Sep 17;2(9):e46. doi: 10.1038/nutd.2012.19.