PMID- 23447092
OWN - NLM
STAT- MEDLINE
DCOM- 20140107
LR  - 20131029
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 48
IP  - 5
DP  - 2013 Nov
TI  - Motor unit firing pattern of vastus lateralis muscle in type 2 diabetes mellitus 
      patients.
PG  - 806-13
LID - 10.1002/mus.23828 [doi]
AB  - INTRODUCTION: We investigated the motor unit (MU) firing pattern in type 2 
      diabetes mellitus (T2DM) patients by means of multichannel surface 
      electromyography (SEMG). METHODS: Eight T2DM patients and 8 age-matched, healthy 
      men performed a ramp-up contraction to 20% of maximal voluntary contraction 
      (MVC). They also performed a sustained contraction at 10% of MVC during isometric 
      knee extension. Multichannel SEMG signals recorded from the vastus lateralis 
      muscle were decomposed with the convolution kernel compensation technique to 
      extract individual MU firing patterns. RESULTS: During the ramp contraction, the 
      extent of MU firing modulation was significantly attenuated in T2DM. Variability 
      of MU firing rate was significantly higher in T2DM at later periods during the 
      sustained contraction. CONCLUSIONS: Our findings suggest that T2DM patients 
      manifest characteristic MU activity patterns due possibly to some degree of 
      neuromuscular impairment affecting the integrity of MU firing modulation.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Watanabe, Kohei
AU  - Watanabe K
AD  - School of International Liberal Studies, Chukyo University, Yagotohonmachi, 
      Showa-ku, Nagoya, 466-8666, Japan; Laboratory of Applied Physiology, Graduate 
      School of Human and Environmental Studies, Kyoto University, Kyoto, Japan.
FAU - Gazzoni, Marco
AU  - Gazzoni M
FAU - Holobar, Ales
AU  - Holobar A
FAU - Miyamoto, Toshiaki
AU  - Miyamoto T
FAU - Fukuda, Kazuhito
AU  - Fukuda K
FAU - Merletti, Roberto
AU  - Merletti R
FAU - Moritani, Toshio
AU  - Moritani T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130830
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Electromyography/instrumentation/*methods
MH  - Humans
MH  - Knee/physiology
MH  - Male
MH  - Muscle Contraction/physiology
MH  - Quadriceps Muscle/innervation/*physiopathology
MH  - Recruitment, Neurophysiological/*physiology
OTO - NOTNLM
OT  - firing rate
OT  - knee extensors
OT  - multichannel surface electromyography
OT  - type 2 diabetes mellitus
OT  - vastus lateralis
EDAT- 2013/03/01 06:00
MHDA- 2014/01/08 06:00
CRDT- 2013/03/01 06:00
PHST- 2013/02/22 00:00 [accepted]
PHST- 2013/03/01 06:00 [entrez]
PHST- 2013/03/01 06:00 [pubmed]
PHST- 2014/01/08 06:00 [medline]
AID - 10.1002/mus.23828 [doi]
PST - ppublish
SO  - Muscle Nerve. 2013 Nov;48(5):806-13. doi: 10.1002/mus.23828. Epub 2013 Aug 30.