PMID- 23447382
OWN - NLM
STAT- MEDLINE
DCOM- 20140325
LR  - 20130814
IS  - 1099-1492 (Electronic)
IS  - 0952-3480 (Linking)
VI  - 26
IP  - 9
DP  - 2013 Sep
TI  - White matter integrity affected by depressive symptoms in migraine without aura: 
      a tract-based spatial statistics study.
PG  - 1103-12
LID - 10.1002/nbm.2924 [doi]
AB  - Previous studies have proven that migraine and depression are bidirectionally 
      linked. However, few studies have investigated white matter (WM) integrity 
      affected by depressive symptoms in patients suffering from migraine without aura 
      (MWoA). Forty patients with MWoA were divided into two groups according to their 
      self-rating depression scale (SDS) score in the present study, including 20 in 
      the SDS (+) (SDS > 49) group and 20 in the SDS (-) (SDS </= 49) group. Forty 
      healthy participants were also recruited as the control group. Tract-based 
      spatial statistics analyses with multiple diffusion tensor imaging-derived 
      indices [fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity 
      (RD), axial diffusivity (AD)] were employed collectively to investigate WM 
      integrity between all patients with MWoA and all healthy controls, between each 
      subgroup (SDS (-) group and SDS (+) group) and healthy controls, and between the 
      SDS (-) and SDS (+) groups. Compared with healthy controls, decreased AD was 
      shown in several WM tracts of the whole MWoA group, SDS (-) group and SDS (+) 
      group. In addition, compared with the SDS (-) group, the SDS (+) group showed 
      decreased FA and increased MD and RD, with conserved AD, including the genu, body 
      and splenium of the corpus callosum, bilateral superior longitudinal fasciculi, 
      the right anterior corona radiata and some other WM tracts, similar to previous 
      findings in depression disorder. Furthermore, mean FA and RD in some of the 
      above-mentioned WM tracts in the SDS (+) group were correlated significantly with 
      SDS scores, including the genu and splenium of the corpus callosum, the right 
      anterior corona radiata and the superior longitudinal fasciculi. Our results 
      suggest that WM integrity may be affected by both depression symptoms (more 
      sensitive as RD) and migraine (more sensitive as AD). The findings may serve as a 
      sensitive biomarker of depression severity in MWoA.
CI  - Copyright (c) 2013 John Wiley & Sons, Ltd.
FAU - Yu, Dahua
AU  - Yu D
AD  - Life Sciences Research Center, School of Life Sciences and Technology, Xidian 
      University, Xi'an, Shaanxi, China.
FAU - Yuan, Kai
AU  - Yuan K
FAU - Zhao, Ling
AU  - Zhao L
FAU - Dong, Minghao
AU  - Dong M
FAU - Liu, Peng
AU  - Liu P
FAU - Yang, Xuejuan
AU  - Yang X
FAU - Liu, Jixin
AU  - Liu J
FAU - Sun, Jinbo
AU  - Sun J
FAU - Zhou, Guangyu
AU  - Zhou G
FAU - Xue, Ting
AU  - Xue T
FAU - Zhao, Limei
AU  - Zhao L
FAU - Cheng, Ping
AU  - Cheng P
FAU - Dong, Tao
AU  - Dong T
FAU - von Deneen, Karen M
AU  - von Deneen KM
FAU - Qin, Wei
AU  - Qin W
FAU - Tian, Jie
AU  - Tian J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130227
PL  - England
TA  - NMR Biomed
JT  - NMR in biomedicine
JID - 8915233
SB  - IM
MH  - Adult
MH  - Anisotropy
MH  - Brain/*pathology
MH  - Case-Control Studies
MH  - Depression/*complications/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Migraine without Aura/*complications/*pathology
MH  - *Statistics as Topic
MH  - Young Adult
OTO - NOTNLM
OT  - anterior corona radiata (ACR)
OT  - corpus callosum (CC)
OT  - depressive symptoms
OT  - migraine without aura (MWoA)
OT  - superior longitudinal fasciculi (SLF)
OT  - tract-based spatial statistics (TBSS)
EDAT- 2013/03/01 06:00
MHDA- 2014/03/26 06:00
CRDT- 2013/03/01 06:00
PHST- 2012/09/02 00:00 [received]
PHST- 2012/12/15 00:00 [revised]
PHST- 2012/12/20 00:00 [accepted]
PHST- 2013/03/01 06:00 [entrez]
PHST- 2013/03/01 06:00 [pubmed]
PHST- 2014/03/26 06:00 [medline]
AID - 10.1002/nbm.2924 [doi]
PST - ppublish
SO  - NMR Biomed. 2013 Sep;26(9):1103-12. doi: 10.1002/nbm.2924. Epub 2013 Feb 27.