PMID- 23448406
OWN - NLM
STAT- MEDLINE
DCOM- 20130909
LR  - 20151119
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 24
IP  - 2
DP  - 2013 Mar
TI  - Dry night cough as a marker of allergy in preschool children: the PARIS birth 
      cohort.
PG  - 131-7
LID - 10.1111/pai.12045 [doi]
AB  - BACKGROUND: Early detection of children at risk for developing allergy is an 
      important challenge. Our first analyses in infants from the Pollution and Asthma 
      Risk: an Infant Study (PARIS) birth cohort suggested that dry night cough was 
      associated with parental-reported allergic disorders. The aim of the present 
      study was to refine this finding by investigating the time course of dry night 
      cough from birth to age 4 yr in relation to blood markers of atopy and allergic 
      morbidity. METHODS: Health outcomes were regularly assessed by parental 
      self-administered questionnaires. Blood markers of atopy were measured at age 
      18 months. Children with similar patterns of dry night cough over the first 4 yr 
      of life were grouped together using k-means clustering. Associations with 
      atopy/allergy were studied using multinomial logistic regression. RESULTS: Three 
      trajectories of dry night cough were identified in 1869 children. Besides the 
      never/infrequent pattern (72.4%), the transient pattern (8.8%) was composed of 
      children who coughed in the first year and recovered by age 4 yr, while the 
      rising pattern (18.8%) included all symptomatic children at age 4 yr, whether 
      they were persistent or late coughers. Compared with the never/infrequent 
      pattern, the rising pattern was significantly associated with elevated total 
      immunoglobulin E (IgE) level (odds ratio [OR] = 1.70, 95% confidence interval 
      [CI] = 1.21-2.39) and inhalant allergens sensitization (OR = 2.66, 95% 
      CI = 1.26-5.61) at age 18 months, and with doctor-diagnosed allergic diseases 
      over the first 4 yr such as hay fever (OR = 2.52, 95% CI = 1.49-4.26) and eczema 
      (OR = 1.29, 95% CI = 1.00-1.66). CONCLUSIONS: This study provides evidence that 
      persistent/late dry night cough may indicate allergy in preschool children.
CI  - (c) 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
FAU - Ranciere, Fanny
AU  - Ranciere F
AD  - Univ Paris Descartes, Sorbonne Paris Cite, EA 4064, Laboratoire Sante Publique et 
      Environnement, Paris, France.
FAU - Nikasinovic, Lydia
AU  - Nikasinovic L
FAU - Momas, Isabelle
AU  - Momas I
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20130301
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Biomarkers/blood
MH  - Child, Preschool
MH  - *Circadian Rhythm
MH  - Cluster Analysis
MH  - Cough/blood/diagnosis/*epidemiology/immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/blood/diagnosis/*epidemiology/immunology
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Infant, Newborn
MH  - Logistic Models
MH  - Male
MH  - Odds Ratio
MH  - Paris/epidemiology
MH  - Prevalence
MH  - Prognosis
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - Time Factors
EDAT- 2013/03/02 06:00
MHDA- 2013/09/10 06:00
CRDT- 2013/03/02 06:00
PHST- 2013/01/03 00:00 [accepted]
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2013/09/10 06:00 [medline]
AID - 10.1111/pai.12045 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2013 Mar;24(2):131-7. doi: 10.1111/pai.12045. Epub 2013 
      Mar 1.