PMID- 23448566
OWN - NLM
STAT- MEDLINE
DCOM- 20130704
LR  - 20130301
IS  - 1744-5205 (Electronic)
IS  - 0882-0538 (Linking)
VI  - 28
IP  - 2
DP  - 2013 Mar
TI  - Retinal nerve fiber layer thickness in children <18 years by spectral-domain 
      optical coherence tomography.
PG  - 97-102
LID - 10.3109/08820538.2012.760626 [doi]
AB  - OBJECTIVES: To establish a normative database for retinal nerve fiber layer 
      (RNFL) thickness in children<18 years by spectral-domain optical coherence 
      tomography (SD-OCT). METHODS: Children <18 years, who were consecutively enrolled 
      from July-August 2011 in this cross-sectional hospital study, underwent Cirrus 
      SD-OCT. Recorded demographics and clinical characteristics included age, sex, 
      axial length, spherical equivalent, intraocular pressure (by Perkins tonometry) 
      and cup disc ratio. The RNFL thickness full circle (RNFL-FC), superior, (RNFL-S), 
      inferior (RNFL-I), temporal (RNFL-T), and nasal (RNFL-N) and the influence of 
      clinical and demographic factors on the RNFL thickness were assessed using linear 
      regression analysis. RESULTS: 148 eyes of 74 children were analyzed (females: 
      males = 37: 37) with a mean age of 10 +/- 3.4 years (range 4-17 years) and a mean 
      spherical equivalent of -0.6 +/- 1.2 dioptres. The mean RNFL-FC was 94 +/- 10.9 and 
      93 +/- 10.6 microm in the right and left eyes, respectively, with maximum thickness 
      found in the superior quadrant. The RNFL-FC and RNFL-S decreased by 1.9 microm for 
      every 1 dioptre increase in myopic shift, p < 0.001, and by 1.9 microm for every mm 
      increase in axial length, p < 0.001. There was no effect of age on RNFL thickness 
      in females or males. CONCLUSIONS: The RNFL thickness in children was influenced 
      most by axial length and refractive error while it was independent of age. The 
      normative data from this study could serve as reference for further studies on 
      pediatric glaucoma using newer imaging devices.
FAU - Rao, Aparna
AU  - Rao A
AD  - Glaucoma Services, LV Prasad Eye Institute, Patia, Bhubaneswar, Orissa, India. 
      vinodini10375@yahoo.com
FAU - Sahoo, Bhaktiprada
AU  - Sahoo B
FAU - Kumar, Mukesh
AU  - Kumar M
FAU - Varshney, Gopal
AU  - Varshney G
FAU - Kumar, Ramesh
AU  - Kumar R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Semin Ophthalmol
JT  - Seminars in ophthalmology
JID - 8610759
SB  - IM
MH  - Adolescent
MH  - Aging/*physiology
MH  - Axial Length, Eye/anatomy & histology
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - *Nerve Fibers
MH  - Optic Nerve/*anatomy & histology
MH  - Reference Values
MH  - Retinal Ganglion Cells/*cytology
MH  - Tomography, Optical Coherence
EDAT- 2013/03/02 06:00
MHDA- 2013/07/05 06:00
CRDT- 2013/03/02 06:00
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2013/07/05 06:00 [medline]
AID - 10.3109/08820538.2012.760626 [doi]
PST - ppublish
SO  - Semin Ophthalmol. 2013 Mar;28(2):97-102. doi: 10.3109/08820538.2012.760626.