PMID- 23449158
OWN - NLM
STAT- MEDLINE
DCOM- 20140801
LR  - 20191112
VI  - 123
IP  - 4
DP  - 2013
TI  - Andropausal syndrome in men with systolic heart failure.
PG  - 156-69
LID - AOP_13_011 [pii]
AB  - INTRODUCTION: Andropausal syndrome (AS) is an element of male aging, being 
      associated with the age-related decline in circulating androgens. OBJECTIVES: We 
      investigated the prevalence of AS, the severity of andropausal symptoms, and 
      their clinical and hormonal determinants in men with heart failure (HF) and 
      healthy peers. PATIENTS AND METHODS: We examined 232 men with systolic HF aged 
      from 40 to 80 years (New York Heart Association [NYHA] class I/II/III-IV: 
      17%/54%/29%, left ventricular ejection fraction: 30% +/-8%) and 362 healthy peers. 
      The severity of 17 andropausal symptoms were assessed using the Aging Males' 
      Symptoms Rating Scale. RESULTS: In men with HF aged from 40 to 59 years, the 
      prevalence of AS and the severity of andropausal symptoms were greater than in 
      healthy peers (28% vs. 7%; 40 +/-14 vs. 35 +/-10 points; both P <0.001), while in the 
      age group of 60 to 80 years, there were no differences in the prevalence of AS 
      and the severity of andropausal symptoms between men with HF and healthy peers 
      (31% vs. 40%; 44 +/-12 vs. 46 +/-10 points; respectively; both P >0.1). In men with 
      HF aged from 40 to 59 years, advanced NYHA class, low hemoglobin, increased 
      platelet number, and low serum dehydroepiandrosterone sulphate were independently 
      associated with the greater prevalence of AS (all P <0.05). In men aged from 60 
      to 80 years, only reduced hemoglobin was borderline related to the higher 
      prevalence of AS (P = 0.07). CONCLUSIONS: AS affects almost one-third of men with 
      HF regardless of the age group. The clinical and hormonal determinants of the 
      severity of andropausal symptoms differ between younger and older male patients. 
      Endocrinological and sexual counseling is recommended in men with HF.
FAU - Tkaczyszyn, Michal
AU  - Tkaczyszyn M
AD  - Students' Scientific Association, Laboratory for Applied Research on 
      Cardiovascular System, Department of Heart Diseases, Wroclaw Medical University, 
      Wroclaw, Poland.
FAU - Nega, Katarzyna
AU  - Nega K
FAU - Lopuszanska, Monika
AU  - Lopuszanska M
FAU - Szklarska, Alicja
AU  - Szklarska A
FAU - Medras, Marek
AU  - Medras M
FAU - Ponikowska, Beata
AU  - Ponikowska B
FAU - von Haehling, Stephan
AU  - von Haehling S
FAU - Doehner, Wolfram
AU  - Doehner W
FAU - Banasiak, Waldemar
AU  - Banasiak W
FAU - Anker, Stefan D
AU  - Anker SD
FAU - Ponikowski, Piotr
AU  - Ponikowski P
FAU - Jankowska, Ewa A
AU  - Jankowska EA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130218
PL  - Poland
TA  - Pol Arch Med Wewn
JT  - Polskie Archiwum Medycyny Wewnetrznej
JID - 0401225
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Andropause/*physiology
MH  - Heart Failure, Systolic/*epidemiology/*physiopathology
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Syndrome
EDAT- 2013/03/02 06:00
MHDA- 2014/08/02 06:00
CRDT- 2013/03/02 06:00
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2014/08/02 06:00 [medline]
AID - AOP_13_011 [pii]
AID - 10.20452/pamw.1680 [doi]
PST - ppublish
SO  - Pol Arch Med Wewn. 2013;123(4):156-69. doi: 10.20452/pamw.1680. Epub 2013 Feb 18.