PMID- 23449323
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20190720
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 36
IP  - 3
DP  - 2013
TI  - Mast cell stabilizing effect of (-)-Elema-1,3,11(13)-trien-12-ol and thujopsene 
      from Thujopsis dolabrata is mediated by down-regulation of interleukin-4 
      secretion in antigen-induced RBL-2H3 cells.
PG  - 339-45
AB  - Several isolated compounds from the wood part of Thujopsis dolabrata were 
      evaluated for their inhibitory effects against antigen-induced mast cell 
      degranulation and interleukin-4 (IL-4) secretion, as well as IL-4 mRNA and 
      protein expression in immunoglobulin E (IgE)-sensitized RBL-2H3 cells. Among the 
      five isolated compounds, (-)-elema-1,3,11(13)-trien-12-ol (1) and thujopsene (2) 
      exhibited the potent inhibitory activity against mast cell degranulation measured 
      by beta-hexosaminidase release with IC values of 27.4 microM and 25.1 microM, respectively. 
      These compounds also inhibited the release of IL-4 (IC values of 7.0, 6.7 microM, 
      respectively), IL-4 mRNA expression (IC values of 16.5, 7.2 microM, respectively) and 
      IL-4 protein expression (IC values of 17.0, 9.6 microM, respectively) in 
      antigen-induced IgE-sensitized RBL-2H3 cells. These results suggested that 
      (-)-elema-1,3,11(13)-trien-12-ol (1) and thujopsene (2) effectively inhibits mast 
      cell degranulation as well as IL-4 production, suggesting that these compounds 
      from Thujopsis dolabrata can be used as candidates for IgE-mediated allergic 
      disorders.
FAU - Kim, Chul-Hee
AU  - Kim CH
AD  - Natural Products Research Institute, College of Pharmacy, Seoul National 
      University.
FAU - Lee, Taehun
AU  - Lee T
FAU - Oh, Ikhoon
AU  - Oh I
FAU - Nam, Kung-Woo
AU  - Nam KW
FAU - Kim, Kyeong Ho
AU  - Kim KH
FAU - Oh, Ki-Bong
AU  - Oh KB
FAU - Shin, Jongheon
AU  - Shin J
FAU - Mar, Woongchon
AU  - Mar W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Sesquiterpenes)
RN  - 0 (elema-1,3,11(13)-trien-12-ol)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - E116U47P7N (thujopsene)
RN  - EC 3.2.1.52 (beta-N-Acetylhexosaminidases)
SB  - IM
MH  - Animals
MH  - Cell Degranulation/drug effects
MH  - Cell Line, Tumor
MH  - Cupressus/*chemistry
MH  - Down-Regulation
MH  - Immunoglobulin E/*immunology
MH  - Interleukin-4/*antagonists & inhibitors/metabolism
MH  - Mast Cells/*drug effects/physiology
MH  - Rats
MH  - Sesquiterpenes/*pharmacology
MH  - beta-N-Acetylhexosaminidases/metabolism
EDAT- 2013/03/02 06:00
MHDA- 2013/08/28 06:00
CRDT- 2013/03/02 06:00
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - DN/JST.JSTAGE/bpb/b12-00375 [pii]
AID - 10.1248/bpb.b12-00375 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2013;36(3):339-45. doi: 10.1248/bpb.b12-00375.