PMID- 23450327
OWN - NLM
STAT- MEDLINE
DCOM- 20140109
LR  - 20211021
IS  - 1931-3543 (Electronic)
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 144
IP  - 2
DP  - 2013 Aug
TI  - Influence of interstitial lung disease on outcome in systemic sclerosis: a 
      population-based historical cohort study.
PG  - 571-577
LID - S0012-3692(13)60534-6 [pii]
LID - 10.1378/chest.12-2768 [doi]
AB  - BACKGROUND: Interstitial lung disease (ILD) is a frequent complication of 
      systemic sclerosis (SSc) and a major cause of SSc-related deaths. This study 
      aimed to determine the influence of ILD on SSc in a population-based historical 
      cohort study. The hypothesis was that patients with SSc who develop ILD have 
      increased morbidity and mortality when compared with patients with SSc without 
      ILD. METHODS: Using the record linkage system of the Rochester Epidemiology 
      Project in Olmsted County, Minnesota, this study identified the incidence of SSc 
      between 1980 and 2010 and point prevalence on December 31, 2010 and determined 
      the progression of organ involvement and its influence on outcome. RESULTS: 
      During the 30-year interval, we identified 64 incident cases of SSc: 57 women and 
      seven men, median age 49.1 years (interquartile range [IQR], 39.8-67.6 years). 
      There were 43 prevalent cases. ILD occurred in 19 cases, usually after the 
      diagnosis of SSc (median, 2 years; IQR, 0-10 years), with only three cases 
      occurring 6 to 24 months beforehand. Pulmonary arterial hypertension (PAH) was 
      diagnosed in 14 cases, heart failure in 27 cases, and chronic kidney disease 
      (CKD) in 21 cases. Seventeen patients died during the study period, with a median 
      survival time after diagnosis of 22.9 years. ILD, PAH, and CKD were associated 
      with an increased risk of death. CONCLUSIONS: The incidence of ILD associated 
      with SSc was relatively low in this population-based cohort. ILD appeared to be a 
      contributing factor to mortality. Other factors, including age, PAH, and CKD, 
      were also associated with poor outcome.
FAU - Bauer, Philippe R
AU  - Bauer PR
AD  - Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN. Electronic 
      address: bauer.philippe@mayo.edu.
FAU - Schiavo, Dante N
AU  - Schiavo DN
AD  - Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
FAU - Osborn, Thomas G
AU  - Osborn TG
AD  - Rheumatology, Mayo Clinic, Rochester, MN.
FAU - Levin, David L
AU  - Levin DL
AD  - Radiology-Diagnostic, Mayo Clinic, Rochester, MN.
FAU - St Sauver, Jennifer
AU  - St Sauver J
AD  - Health Sciences Research-Epidemiology, Mayo Clinic, Rochester, MN.
FAU - Hanson, Andrew C
AU  - Hanson AC
AD  - Health Sciences Research-Biomedical Statistics and Informatics, Mayo Clinic, 
      Rochester, MN.
FAU - Schroeder, Darrell R
AU  - Schroeder DR
AD  - Health Sciences Research-Biomedical Statistics and Informatics, Mayo Clinic, 
      Rochester, MN.
FAU - Ryu, Jay H
AU  - Ryu JH
AD  - Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN.
LA  - eng
GR  - R01 AG034676/AG/NIA NIH HHS/United States
GR  - UL1 TR000135/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
MH  - Adult
MH  - Aged
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Lung Diseases, Interstitial/*etiology/mortality
MH  - Male
MH  - Middle Aged
MH  - Minnesota/epidemiology
MH  - Prevalence
MH  - Risk Factors
MH  - Scleroderma, Systemic/*complications/mortality
PMC - PMC3734889
EDAT- 2013/03/02 06:00
MHDA- 2014/01/10 06:00
PMCR- 2014/08/01
CRDT- 2013/03/02 06:00
PHST- 2013/03/02 06:00 [entrez]
PHST- 2013/03/02 06:00 [pubmed]
PHST- 2014/01/10 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - S0012-3692(13)60534-6 [pii]
AID - chest.12-2768 [pii]
AID - 10.1378/chest.12-2768 [doi]
PST - ppublish
SO  - Chest. 2013 Aug;144(2):571-577. doi: 10.1378/chest.12-2768.