PMID- 23451522
OWN - NLM
STAT- MEDLINE
DCOM- 20140402
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 30
IP  - 11
DP  - 2012 Nov
TI  - [Determination of synthetic nitro-musks in cosmetics by gas chromatography 
      coupled with negative chemical ionization-triple quadrupole mass spectrometry].
PG  - 1178-82
AB  - A confirmatory method is presented for the determination of five nitro-musks 
      (musk ambrette, musk xylene, musk moskene, musk tibeten and musk ketone) in 
      different cosmetics by gas chromatography coupled with negative chemical 
      ionization (NCI)-triple quadrupole mass spectrometry (GC-MS/MS). The samples were 
      extracted under ultrasonication using a mixture of acetone and hexane. The 
      extract was concentrated and then cleaned up by CNWBOND Si solid phase extraction 
      cartridge. Five different instrument parameters such as the temperature 
      programmed, ion source temperature, reagent gas pressure, collision energy, 
      monitoring ion pairs were optimized for higher sensitivity. Then the analytes 
      were qualitatively and quantitatively analyzed under the multiple reaction 
      monitoring (MRM) mode after the chromatographic separation on an HP-5MS capillary 
      column (30 m x 0.25 mm, 0.25 microm), and employing d15-musk xylene as internal 
      standard. The mixed standards were spiked in the blank cosmetics samples (each 
      nitro-musk was about 500 ng/kg), and the recoveries were in the range of 
      85.81%-103.77% with the relative standard deviations (RSDs) not more than 5.32%. 
      The limits of quantification of the method were about 50.0-500 ng/kg. The method 
      is accurate, rapid, sensitive and can be used in the inspection of the five 
      nitro-musks in cosmetics.
FAU - Wang, Zheng
AU  - Wang Z
AD  - Fujian Inspection and Research Institute for Product Quality, National Quality 
      Supervision and Testing Center for Processed Food, Fuzhou 350002, China. 
      syymwan@sina.com
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Cosmetics)
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Perfume)
RN  - 0 (Xylenes)
RN  - 1ZAO16GU5K (musk xylene)
RN  - 483V3E1L6J (musk ketone)
RN  - 83-66-9 (musk ambrette (artificial))
SB  - IM
MH  - Cosmetics/*chemistry
MH  - Dinitrobenzenes/*analysis
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Perfume/analysis
MH  - Solid Phase Extraction/methods
MH  - Xylenes/*analysis
EDAT- 2013/03/05 06:00
MHDA- 2014/04/03 06:00
CRDT- 2013/03/05 06:00
PHST- 2013/03/05 06:00 [entrez]
PHST- 2013/03/05 06:00 [pubmed]
PHST- 2014/04/03 06:00 [medline]
AID - 10.3724/sp.j.1123.2012.07003 [doi]
PST - ppublish
SO  - Se Pu. 2012 Nov;30(11):1178-82. doi: 10.3724/sp.j.1123.2012.07003.