PMID- 23452315
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20131121
IS  - 1029-2292 (Electronic)
IS  - 0897-7194 (Linking)
VI  - 31
IP  - 2
DP  - 2013 Apr
TI  - Effect of growth hormone on dawn phenomenon in patients with type 2 diabetes.
PG  - 66-73
LID - 10.3109/08977194.2013.772996 [doi]
AB  - We aimed to investigate the involvement of growth hormone in dawn phenomenon and 
      insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). On six 
      occasions separated by intervals of at least 3 days, subjects received early 
      evening (16:00 hours) or late night (23:00 hours) pretreatment with subcutaneous 
      injection of normal saline, human growth hormone, or octreotide. Modified 
      euglycemic insulin clamp test was done 16 hours later and variable glucose 
      infusion (M values) was determined. Plasma glucose, serum insulin, insulin-like 
      growth factor-1, non-esterified fatty acids, and metabolic clearance rate of 
      insulin (MCRI) were measured. Early evening application of growth hormone 
      decreased MCRI 16 hours later, suggesting reduction in insulin sensitivity. 
      Exogenous growth hormone injection reduced insulin sensitivity in T2DM patients. 
      Results provide direct evidence for the role of growth hormone in regulating the 
      insulin sensitivity in insulin-resistant patients.
FAU - Shih, Kuang-Chung
AU  - Shih KC
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Taipei-Veterans 
      General Hospital, Taipei 112, Taiwan.
FAU - Hsieh, Sheng-Hwu
AU  - Hsieh SH
FAU - Kwok, Ching-Fai
AU  - Kwok CF
FAU - Hwu, Chii-Min
AU  - Hwu CM
FAU - Hsieh, Po-Shiuan
AU  - Hsieh PS
FAU - Ho, Low-Tone
AU  - Ho LT
LA  - eng
PT  - Journal Article
DEP - 20130301
PL  - England
TA  - Growth Factors
JT  - Growth factors (Chur, Switzerland)
JID - 9000468
RN  - 0 (Blood Glucose)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - RWM8CCW8GP (Octreotide)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 2/*blood/drug therapy
MH  - *Drug Chronotherapy
MH  - Female
MH  - Glucose Clamp Technique
MH  - Human Growth Hormone/administration & dosage/*blood/*pharmacology
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Octreotide/administration & dosage/blood/pharmacology
EDAT- 2013/03/05 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/03/05 06:00
PHST- 2013/03/05 06:00 [entrez]
PHST- 2013/03/05 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 10.3109/08977194.2013.772996 [doi]
PST - ppublish
SO  - Growth Factors. 2013 Apr;31(2):66-73. doi: 10.3109/08977194.2013.772996. Epub 
      2013 Mar 1.