PMID- 23456645
OWN - NLM
STAT- MEDLINE
DCOM- 20150519
LR  - 20140915
IS  - 1521-4028 (Electronic)
IS  - 0233-111X (Linking)
VI  - 54
IP  - 9
DP  - 2014 Sep
TI  - Toxic behavior of silver and zinc oxide nanoparticles on environmental 
      microorganisms.
PG  - 916-27
LID - 10.1002/jobm.201200316 [doi]
AB  - Silver and zinc oxide nanoparticles (Ag and ZnO NPs) are widely used as 
      antimicrobial agents. However, their potential toxicological impact on 
      environmental microorganisms is largely unexplored. The aim of this work was to 
      investigate the sensitivity and adaptability of five bacterial species isolated 
      from sewage towards Ag and ZnO NPs. The bacterial species were exposed to 
      increasing concentration of nanoparticles and the growth inhibitory effect, 
      exopolysaccharides (EPSs) and extracellular proteins (ECPs) productions were 
      determined. The involvement of surface charge in nanoparticles toxicity was also 
      determined. The bacterial species were constantly exposed to nanoparticles to 
      determine the adaptation behavior toward nanoparticles. The nanoparticles 
      exhibited remarkable growth inhibitory effect on tested bacterial species. The 
      toxicity of nanoparticles was found to be strongly dependent on surface charge 
      effects. Though, these organisms are highly sensitive to Ag and ZnO NPs, the 
      continuous exposure to these nanoparticles leads to moderate adaptation of 
      bacterial species and the adapted bacterial species convert the highly toxic nano 
      form to less toxic microform. Finally we predict that the continuing applications 
      of nanoparticles in consumer products may lead to the development of 
      nanoparticles resistant bacterial strains in future.
CI  - (c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Dhas, Sindhu Priya
AU  - Dhas SP
AD  - Centre for Nanobiotechnology, VIT University, Tamil Nadu, India.
FAU - Shiny, Punalur John
AU  - Shiny PJ
FAU - Khan, Sudheer
AU  - Khan S
FAU - Mukherjee, Amitava
AU  - Mukherjee A
FAU - Chandrasekaran, Natrajan
AU  - Chandrasekaran N
LA  - eng
PT  - Journal Article
DEP - 20130301
PL  - Germany
TA  - J Basic Microbiol
JT  - Journal of basic microbiology
JID - 8503885
RN  - 0 (Bacterial Proteins)
RN  - 0 (Polysaccharides, Bacterial)
RN  - 0 (Sewage)
RN  - 3M4G523W1G (Silver)
RN  - SOI2LOH54Z (Zinc Oxide)
SB  - IM
MH  - Adaptation, Physiological
MH  - Bacteria/*drug effects/growth & development/isolation & purification/metabolism
MH  - Bacterial Proteins/metabolism
MH  - Drug Tolerance
MH  - Nanoparticles/chemistry/*toxicity
MH  - Polysaccharides, Bacterial/metabolism
MH  - Sewage/*microbiology
MH  - Silver/*toxicity
MH  - Static Electricity
MH  - Zinc Oxide/*toxicity
OTO - NOTNLM
OT  - Adaptation
OT  - Antimicrobial activity
OT  - Exopolysaccharides
OT  - Nanoparticles
OT  - Zeta potential
EDAT- 2013/03/05 06:00
MHDA- 2015/05/20 06:00
CRDT- 2013/03/05 06:00
PHST- 2012/06/06 00:00 [received]
PHST- 2012/08/14 00:00 [accepted]
PHST- 2013/03/05 06:00 [entrez]
PHST- 2013/03/05 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - 10.1002/jobm.201200316 [doi]
PST - ppublish
SO  - J Basic Microbiol. 2014 Sep;54(9):916-27. doi: 10.1002/jobm.201200316. Epub 2013 
      Mar 1.