PMID- 23457005
OWN - NLM
STAT- MEDLINE
DCOM- 20140722
LR  - 20181202
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 42
IP  - 1
DP  - 2014 Jan
TI  - A case of anaplastic lymphoma kinase-positive large B-cell lymphoma: aspiration 
      cytology findings.
PG  - 69-72
LID - 10.1002/dc.22968 [doi]
AB  - Anaplastic lymphoma kinase-positive (ALK+) large B-cell lymphoma (LBCL) is a rare 
      subtype of non-Hodgkin B-cell lymphoma that exhibits a more aggressive clinical 
      course and poorer prognosis than the typical diffuse large B-cell lymphoma. In 
      this study, we report the case of a 67-year-old man with left cervical lymph node 
      swelling. Aspiration cytology revealed many clusters of cohesive, large, and 
      solitary cells. The tumor cells had abundant cytoplasm and large round-to-oval 
      nuclei with prominent nucleoli. The Giemsa staining specimens exhibited amorphous 
      global bodies adjacent to some clusters. Histologically, large tumor cells 
      occupied the lymph nodes in a sinusoidal pattern, and immunohistochemically, 
      these cells were cytokeratin-, CD19(-), CD20(-), CD79a(-), CD3(-), CD30(-), 
      CD138(+), IgG(-), IgA(+), and ALK(+). Chromogenic in situ hybridization revealed 
      restricted immunoglobulin light-chain expression. Fluorescent in situ 
      hybridization demonstrated translocation of the ALK gene. The tumor cells were 
      negative for Epstein-Barr virus and human herpesvirus 8. It is important to 
      differentiate ALK+LBCL from metastatic carcinoma and other lymphoma subtypes with 
      similar histological features to ensure a proper treatment strategy and 
      prediction of prognosis.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Nakatsuka, Shin-ichi
AU  - Nakatsuka S
AD  - Department of Pathology, Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.
FAU - Oku, Kazuko
AU  - Oku K
FAU - Nagano, Teruaki
AU  - Nagano T
FAU - Kimura, Hayato
AU  - Kimura H
FAU - Hanamoto, Atsushi
AU  - Hanamoto A
FAU - Ito, Mahito
AU  - Ito M
FAU - Hashimoto, Koji
AU  - Hashimoto K
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130301
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Aged
MH  - Anaplastic Lymphoma Kinase
MH  - Biopsy, Needle
MH  - Humans
MH  - Lymphoma, B-Cell/*chemistry/enzymology/genetics/*pathology/therapy
MH  - Male
MH  - Receptor Protein-Tyrosine Kinases/*analysis/genetics
MH  - Translocation, Genetic
OTO - NOTNLM
OT  - anaplastic lymphoma kinase
OT  - aspiration cytology
OT  - cohesiveness
OT  - large B-cell lymphoma
EDAT- 2013/03/05 06:00
MHDA- 2014/07/23 06:00
CRDT- 2013/03/05 06:00
PHST- 2012/05/18 00:00 [received]
PHST- 2012/10/26 00:00 [revised]
PHST- 2013/01/01 00:00 [accepted]
PHST- 2013/03/05 06:00 [entrez]
PHST- 2013/03/05 06:00 [pubmed]
PHST- 2014/07/23 06:00 [medline]
AID - 10.1002/dc.22968 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2014 Jan;42(1):69-72. doi: 10.1002/dc.22968. Epub 2013 Mar 1.