PMID- 23457673
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20220321
IS  - 1916-7245 (Electronic)
IS  - 1198-2241 (Print)
IS  - 1198-2241 (Linking)
VI  - 20
IP  - 1
DP  - 2013 Jan-Feb
TI  - Local and systemic oxidative stress status in chronic obstructive pulmonary 
      disease patients.
PG  - 35-41
AB  - BACKGROUND: Previous studies have indicated that oxidative stress plays an 
      important role in the pathogenesis of chronic obstructive pulmonary disease 
      (COPD). OBJECTIVES: To study local and systemic oxidative stress status in COPD 
      patients, and to clarify the relationship between local and systemic oxidative 
      stress. METHODS: Lipid peroxide malondialdehyde (MDA), glutathione (GSH), 
      superoxide dismutase (SOD) and GSH peroxidase (GSH-PX) levels in induced sputum 
      and plasma, as well as glucocorticoid receptor (GR) levels in peripheral blood 
      leukocytes were examined in 43 acute exacerbation of COPD patients (group A), 35 
      patients with stable COPD (group B) and 28 healthy controls (14 smokers [group 
      C]; 14 nonsmokers [group D]). RESULTS: MDA levels in induced sputum and plasma 
      decreased progressively in groups A to D, with significant differences between 
      any two groups (P<0.001). GSH, SOD and GSH-PX levels in both induced sputum and 
      plasma increased progressively in groups A to D, with significant differences 
      between any two groups (P<0.001). GR levels in peripheral blood leukocytes 
      decreased progressively in groups D to A (all comparisons P<0.001). Pearson 
      analysis revealed strong correlations between MDA, GSH, SOD and GSH-PX levels in 
      plasma and induced sputum. The activity of SOD in plasma and sputum were both 
      positively correlated with GR levels (partial correlation coefficients 0.522 and 
      0.574, respectively [P<0.001]). CONCLUSIONS: Oxidative stress levels were 
      elevated in COPD patients. There was a correlation between local and systemic 
      oxidative status in COPD, and between decreased SOD activity and decreased GR 
      levels in COPD patients.
FAU - Zeng, Mian
AU  - Zeng M
AD  - Department of Respiratory Medicine, First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, People's Republic of China. zengmian2004@163.com
FAU - Li, Yue
AU  - Li Y
FAU - Jiang, Yujie
AU  - Jiang Y
FAU - Lu, Guifang
AU  - Lu G
FAU - Huang, Xiaomei
AU  - Huang X
FAU - Guan, Kaipan
AU  - Guan K
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - Can Respir J
JT  - Canadian respiratory journal
JID - 9433332
RN  - 0 (Receptors, Glucocorticoid)
SB  - IM
CIN - Can Respir J. 2013 Jan-Feb;20(1):27-9. PMID: 23457671
MH  - Aged
MH  - Female
MH  - Humans
MH  - Leukocytes/chemistry/metabolism
MH  - Male
MH  - *Oxidative Stress
MH  - Pulmonary Disease, Chronic Obstructive/blood/*metabolism
MH  - Receptors, Glucocorticoid/analysis/metabolism
PMC - PMC3628645
EDAT- 2013/03/05 06:00
MHDA- 2013/10/18 06:00
PMCR- 2014/01/01
CRDT- 2013/03/05 06:00
PHST- 2013/03/05 06:00 [entrez]
PHST- 2013/03/05 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - crj20035 [pii]
AID - 10.1155/2013/985382 [doi]
PST - ppublish
SO  - Can Respir J. 2013 Jan-Feb;20(1):35-41. doi: 10.1155/2013/985382.