PMID- 23459078
OWN - NLM
STAT- MEDLINE
DCOM- 20131114
LR  - 20130503
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 74
IP  - 6
DP  - 2013 Jun
TI  - Genetic study confirms association of HLA-DPA1( *)01:03 subtype with ankylosing 
      spondylitis in HLA-B27-positive populations.
PG  - 764-7
LID - S0198-8859(13)00050-5 [pii]
LID - 10.1016/j.humimm.2013.02.001 [doi]
AB  - The association of human leukocyte antigen (HLA)-B27 with ankylosing spondylitis 
      (AS) has been known for over 38 years. However, it is not the only gene 
      associated with AS. The aim of this study was to confirm the association of HLA 
      markers around HLA-DPA1/DPB1 region with AS in HLA-B27 positive populations. Five 
      SNPs (rs422544, rs6914849, rs92777535, rs3128968 and rs2295119) from the 
      HLA-DPA1/DPB1 region were genotyped in 340 individuals HLA-B27-positive from 
      Portugal (137 AS patients and 203 healthy controls). Characterizations of 
      HLA-DPA1/DPB1 alleles were also performed. rs422544 revealed a significant 
      association with AS (P<0.05) and sliding windows (SW) analysis showed association 
      of some groups of adjacent SNPs within HLA-DPA1/DPB1 region with AS (P<0.05). We 
      also found association of the HLA-DPA1( *)01:03 allele with AS (P<0.05). This is 
      the first study that confirms the association of HLA markers and haplotypes 
      around HLA-DPA1 and HLA-DPB1 with AS.
CI  - Copyright (c) 2013 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Diaz-Pena, Roberto
AU  - Diaz-Pena R
AD  - Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, 
      Spain.
FAU - Castro-Santos, Patricia
AU  - Castro-Santos P
FAU - Aransay, Ana M
AU  - Aransay AM
FAU - Bruges-Armas, Jacome
AU  - Bruges-Armas J
FAU - Pimentel-Santos, Fernando M
AU  - Pimentel-Santos FM
FAU - Lopez-Larrea, Carlos
AU  - Lopez-Larrea C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130228
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DP alpha-Chains)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPA1 antigen)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*genetics/immunology
MH  - HLA-DP alpha-Chains/*genetics/immunology
MH  - HLA-DP beta-Chains/genetics/immunology
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Spondylitis, Ankylosing/*genetics/immunology
EDAT- 2013/03/06 06:00
MHDA- 2013/11/15 06:00
CRDT- 2013/03/06 06:00
PHST- 2012/08/17 00:00 [received]
PHST- 2013/01/15 00:00 [revised]
PHST- 2013/02/19 00:00 [accepted]
PHST- 2013/03/06 06:00 [entrez]
PHST- 2013/03/06 06:00 [pubmed]
PHST- 2013/11/15 06:00 [medline]
AID - S0198-8859(13)00050-5 [pii]
AID - 10.1016/j.humimm.2013.02.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2013 Jun;74(6):764-7. doi: 10.1016/j.humimm.2013.02.001. Epub 2013 
      Feb 28.