PMID- 23459080
OWN - NLM
STAT- MEDLINE
DCOM- 20131114
LR  - 20130503
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 74
IP  - 6
DP  - 2013 Jun
TI  - Human leukocyte antigen class I alleles and haplotypes associated with primary 
      hepatocellular carcinoma in persistent HBV-infected patients.
PG  - 758-63
LID - S0198-8859(13)00056-6 [pii]
LID - 10.1016/j.humimm.2013.02.007 [doi]
AB  - Many studies have shown that Human leukocyte antigen (HLA) class I alleles are 
      associated with the development of various cancers. However, its role in 
      hepatocellular carcinoma (HCC) is still unknown. To investigate whether HLA class 
      I allelic polymorphism is related to the development of hepatitis B 
      virus(HBV)-associated HCC, a total of 326 HBV-infected patients (138 individuals 
      with HCC and 188 well-matched controls without HCC) were enrolled in this study. 
      HLA-A, -B, and -C were genotyped by polymerase chain reaction-sequencing based 
      typing (PCR-SBT) method. We identified HLA-B( *)35:01:01G as a risk factor for 
      HBV-related HCC development independent of our previous findings in HLA region 
      (OR, 12.04; p, 0.0028; pc, 0.04). HLA-A( *)11:01:01G, B( *)58:01:01G, C( *)03:02:01G 
      and some of their extended haplotypes were found as potential susceptible factors 
      for HCC development. HLA-B( *)46:01:01G and some of its extended haplotypes were 
      found as potential protective factors for HCC development. Our results support 
      that specific HLA class I alleles and haplotypes may affect the risk of 
      HBV-related HCC development. The findings may help to determine better approaches 
      for prevention and treatment of HCC in these patients.
CI  - Copyright (c) 2013 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Pan, Ning
AU  - Pan N
AD  - Department of Immunology and Pathogen Biology, Medical School, Southeast 
      University, Nanjing 210009, China.
FAU - Chen, Keping
AU  - Chen K
FAU - Qiu, Jie
AU  - Qiu J
FAU - Sun, Hang
AU  - Sun H
FAU - Xu, Jinhuan
AU  - Xu J
FAU - Miao, Fengqin
AU  - Miao F
FAU - Shi, Qian
AU  - Shi Q
FAU - Jiang, Wei
AU  - Jiang W
FAU - Jin, Hui
AU  - Jin H
FAU - He, Youji
AU  - He Y
FAU - Xie, Wei
AU  - Xie W
FAU - Zhang, Jianqiong
AU  - Zhang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130301
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Carcinoma, Hepatocellular/*complications/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - *Haplotypes
MH  - Hepatitis B virus
MH  - Hepatitis B, Chronic/*complications
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Liver Cirrhosis/complications
MH  - Liver Neoplasms/*complications/*genetics
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
EDAT- 2013/03/06 06:00
MHDA- 2013/11/15 06:00
CRDT- 2013/03/06 06:00
PHST- 2012/06/19 00:00 [received]
PHST- 2013/01/18 00:00 [revised]
PHST- 2013/02/19 00:00 [accepted]
PHST- 2013/03/06 06:00 [entrez]
PHST- 2013/03/06 06:00 [pubmed]
PHST- 2013/11/15 06:00 [medline]
AID - S0198-8859(13)00056-6 [pii]
AID - 10.1016/j.humimm.2013.02.007 [doi]
PST - ppublish
SO  - Hum Immunol. 2013 Jun;74(6):758-63. doi: 10.1016/j.humimm.2013.02.007. Epub 2013 
      Mar 1.