PMID- 23460185
OWN - NLM
STAT- MEDLINE
DCOM- 20130624
LR  - 20220321
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Print)
IS  - 0021-9541 (Linking)
VI  - 228
IP  - 8
DP  - 2013 Aug
TI  - mTOR signaling for biological control and cancer.
PG  - 1658-64
LID - 10.1002/jcp.24351 [doi]
AB  - Mammalian target of rapamycin (mTOR) is a major intersection that connects 
      signals from the extracellular milieu to corresponding changes in intracellular 
      processes. When abnormally regulated, the mTOR signaling pathway is implicated in 
      a wide spectrum of cancers, neurological diseases, and proliferative disorders. 
      Therefore, pharmacological agents that restore the regulatory balance of the mTOR 
      pathway could be beneficial for a great number of diseases. This review 
      summarizes current understanding of mTOR signaling and some unanswered questions 
      in the field. We describe the composition of the mTOR complexes, upstream signals 
      that activate mTOR, and physiological processes that mTOR regulates. We also 
      discuss the role of mTOR and its downstream effectors in cancer, obesity and 
      diabetes, and autism.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Alayev, Anya
AU  - Alayev A
AD  - Department of Biology, Stern College for Women of Yeshiva University, New York, 
      New York 10016, USA.
FAU - Holz, Marina K
AU  - Holz MK
LA  - eng
GR  - R15 CA151112/CA/NCI NIH HHS/United States
GR  - CA151112/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Multiprotein Complexes)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Mechanistic Target of Rapamycin Complex 2
MH  - Multiprotein Complexes/antagonists & inhibitors/physiology
MH  - Neoplasms/*enzymology
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases/antagonists & inhibitors/*physiology
PMC - PMC4491917
MID - NIHMS548956
EDAT- 2013/03/06 06:00
MHDA- 2013/06/26 06:00
PMCR- 2015/07/06
CRDT- 2013/03/06 06:00
PHST- 2013/02/07 00:00 [received]
PHST- 2013/02/12 00:00 [accepted]
PHST- 2013/03/06 06:00 [entrez]
PHST- 2013/03/06 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
PHST- 2015/07/06 00:00 [pmc-release]
AID - 10.1002/jcp.24351 [doi]
PST - ppublish
SO  - J Cell Physiol. 2013 Aug;228(8):1658-64. doi: 10.1002/jcp.24351.