PMID- 23460403
OWN - NLM
STAT- MEDLINE
DCOM- 20140211
LR  - 20160511
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 3
IP  - 7
DP  - 2013 Jul
TI  - Upper airway inflammation exacerbates bronchial hyperreactivity in mouse models 
      of rhinosinusitis and allergic asthma.
PG  - 532-42
LID - 10.1002/alr.21160 [doi]
AB  - BACKGROUND: Recent studies have suggested that upper airway inflammation has a 
      strong impact on lower airway diseases. The purpose of this study was to assess 
      whether nasal inflammation could exacerbate allergic asthma in a mouse model. 
      METHODS: Mice were assigned to 4 groups: control (Cont), either rhinosinusitis 
      (R) or allergic asthma (A) alone, and both rhinosinusitis and allergic asthma 
      (R&A). Mice underwent induction of nasal inflammation (R and R&A) or sham surgery 
      (Cont and A) on day 1. Mice in the A and R&A groups were sensitized to ovalbumin 
      on days 1, 7, and 14, followed by aerosol challenge on days 18 to 20, whereas in 
      the Cont and R groups only saline was administered. All mice were assessed for 
      airway hyperresponsiveness (AHR) and were euthanized on day 21. The sera, 
      bronchoalveolar lavage fluids (BALFs), and nasal and lung tissues were collected 
      for further analyses. RESULTS: Histology findings confirmed upper and lower 
      airway inflammation in experimental mice. Significantly increased AHR and total 
      serum immunoglobulin E (IgE) were observed in the R&A group when compared with 
      those of the Cont, R, and A groups. Responses to IgG2a induction were also found 
      in sera and BALFs from mice with rhinosinusitis (R and R&A). Higher levels of 
      interleukin 4 (IL-4) and IL-13, and increased eosinophilic inflammation were 
      detected in BALFs and lung tissues from the experimental groups when compared 
      with those from the Cont group. CONCLUSION: Our results confirm that upper airway 
      inflammation could exacerbate allergic asthma, and provide support to the concept 
      of "one airway, one disease.
CI  - (c) 2013 ARS-AAOA, LLC.
FAU - Liang, Kai-Li
AU  - Liang KL
AD  - Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, 
      Taiwan.
FAU - Jiang, Rong-San
AU  - Jiang RS
FAU - Wang, Ren-Ching
AU  - Wang RC
FAU - Koo, Malcolm
AU  - Koo M
FAU - Chen, Shyh-Chang
AU  - Chen SC
FAU - Huang, Wan-Chun
AU  - Huang WC
FAU - Yeh, Yueh-Chiao
AU  - Yeh YC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130304
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Allergens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-13)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Allergens/administration & dosage
MH  - Animals
MH  - Asthma/immunology/pathology/*physiopathology
MH  - Bronchial Hyperreactivity/immunology/pathology/*physiopathology
MH  - Bronchial Provocation Tests
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - Disease Models, Animal
MH  - Immunoglobulin E/blood/immunology
MH  - Immunoglobulin G/blood/immunology
MH  - Interleukin-13/immunology
MH  - Interleukin-4/immunology
MH  - Leukocyte Count
MH  - Lung/immunology/pathology/physiopathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nasal Cavity/pathology
MH  - Ovalbumin/administration & dosage
MH  - Rhinitis/immunology/pathology/*physiopathology
MH  - Sinusitis/immunology/pathology/*physiopathology
OTO - NOTNLM
OT  - allergen
OT  - allergic rhinitis
OT  - asthma
OT  - bronchial hyperreactivity
OT  - mouse
OT  - ovalbumin
OT  - rhinosinusitis
EDAT- 2013/03/06 06:00
MHDA- 2014/02/12 06:00
CRDT- 2013/03/06 06:00
PHST- 2012/09/28 00:00 [received]
PHST- 2012/11/21 00:00 [revised]
PHST- 2013/01/22 00:00 [accepted]
PHST- 2013/03/06 06:00 [entrez]
PHST- 2013/03/06 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
AID - 10.1002/alr.21160 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2013 Jul;3(7):532-42. doi: 10.1002/alr.21160. Epub 2013 
      Mar 4.