PMID- 23460411
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20130621
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Linking)
VI  - 23
IP  - 7
DP  - 2013 Jul
TI  - Representational demands modulate involvement of perirhinal cortex in face 
      processing.
PG  - 592-605
LID - 10.1002/hipo.22117 [doi]
AB  - The classic view holds that the medial temporal lobes (MTL) are dedicated to 
      declarative memory functioning. Recent evidence, however, suggests that 
      perirhinal cortex (PrC), a structure within the anterior MTL, may also play a 
      role in perceptual discriminations when representations of complex conjunctions 
      of features, or of gestalt-characteristics of objects must be generated. 
      Interestingly, neuroimaging and electrophysiological recordings in nonhuman 
      primates have also revealed a face patch in the anterior collateral sulcus with 
      preferential responses to face stimuli in various task contexts. In the present 
      fMRI study, we investigated the representational demands that influence PrC 
      involvement in different types of judgments on human faces. Holding stimulus 
      complexity constant, we independently manipulated the nature of the task and the 
      orientation of the stimuli presented (through face inversion). Aspects of right 
      PrC showed increased responses in a forced-choice recognition-memory and a 
      perceptual-oddity task, as compared to a feature-search task that was included to 
      probe visual detection of an isolated face feature. Effects of stimulus 
      orientation in right PrC were observed when the recognition-memory condition for 
      upright faces was compared with all other experimental conditions, including 
      recognition-memory for inverted faces-a result that can be related to past work 
      on the role of PrC in object unitization. Notably, both effects in right PrC 
      paralleled activity patterns in broader networks of regions that also included 
      the right fusiform gyrus and the amygdala, regions frequently implicated in face 
      processing in prior research. As such, the current findings do not support the 
      view that reference to a prior study episode clearly distinguishes the role of 
      PrC from that of more posterior ventral visual pathway regions. They add to a 
      growing body of evidence suggesting that the functional role of specific MTL 
      structures may be best understood in terms of the representations that are 
      required by the task and the stimuli at hand.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - O'Neil, Edward B
AU  - O'Neil EB
AD  - The Brain and Mind Institute, University of Western Ontario, London, Ontario, 
      Canada.
FAU - Barkley, Victoria A
AU  - Barkley VA
FAU - Kohler, Stefan
AU  - Kohler S
LA  - eng
GR  - MOP93644/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130412
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
SB  - IM
MH  - Adult
MH  - *Brain Mapping
MH  - Face
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory/physiology
MH  - Pattern Recognition, Visual/*physiology
MH  - Photic Stimulation
MH  - Temporal Lobe/*physiology
MH  - Young Adult
EDAT- 2013/03/06 06:00
MHDA- 2014/01/24 06:00
CRDT- 2013/03/06 06:00
PHST- 2013/02/27 00:00 [accepted]
PHST- 2013/03/06 06:00 [entrez]
PHST- 2013/03/06 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
AID - 10.1002/hipo.22117 [doi]
PST - ppublish
SO  - Hippocampus. 2013 Jul;23(7):592-605. doi: 10.1002/hipo.22117. Epub 2013 Apr 12.